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• W1978491570 endingPage "876" @default.
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• W1978491570 abstract "The present study investigated the regulation of spontaneous neuronal activity in the subthalamic nucleus by dopamine receptors using in vivo extracellular single unit recording techniques. Subthalamic nucleus neuronal firing rates were doubled by systemic administration of the nonselective dopamine receptor agonist apomorphine. The response to apomorphine was attenuated in animals anesthetized with chloral hydrate or ketamine. The dopamine D2D3 receptor agonist quinpirole did not alter subthalamic nucleus neuronal firing rates. Firing rates were increased by the D1 receptor agonists SKF 38393 and SKF 82958 two- to three-fold; these increases were reversed by the D1 receptor antagonist, SCH 23390. Autoradiographic studies using [125I]SCH 23982 indicated that D1 family receptors were located along the ventral edge of the subthalamic nucleus and the dorsal aspect of the cerebral peduncle. Local administration of SKF 82958 into the subthalamic nucleus doubled neuronal firing rates; these increases were reversed by systemic administration of SCH 23390. Infusion of SCH 23390 into the subthalamic nucleus prevented systemic SKF 38393 from increasing the firing rates of subthalamic nucleus neurons. These results indicate that apomorphine and D1 receptor agonists exert an excitatory influence on subthalamic nucleus neuronal activity. In addition, the excitation induced by D1 receptor agonists appears to be mediated, at least in part, by D1 receptors located in the vicinity of the subthalamic nucleus. The data suggest that basal ganglia output under conditions of increased dopamine receptor stimulation is influenced by the activation of excitatory subthalamic efferent pathways, as opposed to suppression of these pathways as predicted by current models of basal ganglia function." @default.
• W1978491570 created "2016-06-24" @default.
• W1978491570 creator A5034511392 @default.
• W1978491570 creator A5049697442 @default.
• W1978491570 creator A5089173734 @default.
• W1978491570 date "1996-06-01" @default.
• W1978491570 modified "2023-10-16" @default.
• W1978491570 title "Apomorphine and dopamine D1 receptor agonists increase the firing rates of subthalamic nucleus neurons" @default.
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• W1978491570 doi "https://doi.org/10.1016/0306-4522(95)00583-8" @default.
• W1978491570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9157332" @default.
• W1978491570 hasPublicationYear "1996" @default.
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