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- W1978492794 abstract "We have studied protein acylation using [3H]myristate in the two leukemia cell lines HL-60 and HL-60 Blast II. The latter is a variant which does not differentiate after treatment with 12-O-tetradecanoyl phorbol 13-acetate (TPA). The acylation profiles of the two cell lines as examined by SDS-PAGE differed. TPA induced the myristylation of an ∼ 82 kDa protein in the sensitive cells, but not in the resistant cells. Myristic acid was shown to be covalently linked to these proteins. Analysis of the cell lipids labelled with [3H]myristate showed that in contrast to observations with the proteins, the changes induced by TPA were observed in both TPA-sensitive and TPA-resistant cells. We conclude that the induction of myristylation may be an important step in the mechanism of differentiation." @default.
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- W1978492794 date "1987-05-04" @default.
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- W1978492794 title "12-O-Tetradecanoyl phorbol 13-acetate stimulates the myristylation of an ∼ 82 kDa protein in HL-60 cells" @default.
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- W1978492794 doi "https://doi.org/10.1016/0014-5793(87)80136-9" @default.
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