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• W1978493362 abstract "The neurotransmitter dopamine counteracts T cell functions through its specific receptor subtype D5R but favors T cell proliferation and adhesion when acting on D3R. We found diminished mRNA and protein levels of D5R, but not of D3R, in peripheral blood mononuclear cells (PBMCs) from untreated multiple sclerosis (MS) patients. Dopamine reduced T cell proliferation, secretion of interferon-γ (IFN-γ), and production of matrix metalloproteinase-9 (MMP-9) mRNA in PBMCs from controls but not from MS patients. By contrast, reduced levels of D3R and renewed dopamine-associated regulatory functions were found in PBMCs from IFN-β treated MS patients. Failure of the dopaminergic system of lymphocytes may lessen the threshold of T cell activation and sustain the pathogenic cascade of MS." @default.
• W1978493362 created "2016-06-24" @default.
• W1978493362 creator A5006756584 @default.
• W1978493362 creator A5023725739 @default.
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• W1978493362 date "2005-07-01" @default.
• W1978493362 modified "2023-10-06" @default.
• W1978493362 title "Dopamine Fails to Regulate Activation of Peripheral Blood Lymphocytes from Multiple Sclerosis Patients: Effects of IFN-β" @default.
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• W1978493362 doi "https://doi.org/10.1089/jir.2005.25.395" @default.
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