Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978493563> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1978493563 endingPage "1868" @default.
- W1978493563 startingPage "1868" @default.
- W1978493563 abstract "Purpose.: To examine the potential for benzalkonium chloride (BAK) to cause denervation of the orbicularis oculi muscle (OOM) in a rabbit model. Methods.: Pigmented rabbits were separated into five groups consisting of five rabbits each. Group 1 was injected with 1 mL of BAK 0.25% in the OOM of the upper eyelid. Group 2 was injected with 1 mL of BAK 0.5%. Group 3 included untreated controls. Groups 4 and 5 underwent surgical severing of the facial nerve (to cause complete paralysis of the OOM). Strength-duration curves for electrical stimulation of muscle twitches were measured for each group and chronaxie values were calculated to determine innervation status. Groups 1 and 4 were stimulated at 1 week postintervention while groups 2 and 5 were stimulated at 4 weeks postintervention. The rabbits were then sacrificed and the eyelids sent for histological analysis. Results.: In group 1, all five rabbits demonstrated denervation of the OOM in the injected area. In group 2, one rabbit developed an abscess at the injection site and was sacrificed at 1 week. Of the remaining four rabbits, two showed complete denervation and two showed denervation with evidence of partial reinnervation. The histology demonstrated marked atrophy of the OOM for BAK-treated rabbits when compared with controls. In group 3, all five rabbits showed normal OOM function. In groups 4 and 5, all rabbits showed denervation of the OOM and histological evidence of muscle atrophy similar to groups 1 and 2. Conclusions.: BAK causes denervation when injected into the OOM in rabbits. The clinical relevance of this finding may be the onset of lagophthalmos and eyelid retraction in patients with chronic BAK exposure." @default.
- W1978493563 created "2016-06-24" @default.
- W1978493563 creator A5017335738 @default.
- W1978493563 creator A5034055970 @default.
- W1978493563 creator A5047793069 @default.
- W1978493563 creator A5061895901 @default.
- W1978493563 date "2013-03-13" @default.
- W1978493563 modified "2023-10-17" @default.
- W1978493563 title "Benzalkonium Chloride–Induced Denervation of Orbicularis Oculi Muscle in Rabbits" @default.
- W1978493563 cites W10553023 @default.
- W1978493563 cites W1510804602 @default.
- W1978493563 cites W1892634360 @default.
- W1978493563 cites W1966097749 @default.
- W1978493563 cites W1970731633 @default.
- W1978493563 cites W1973633538 @default.
- W1978493563 cites W1984656953 @default.
- W1978493563 cites W2006666602 @default.
- W1978493563 cites W2009259670 @default.
- W1978493563 cites W2014115280 @default.
- W1978493563 cites W2027546474 @default.
- W1978493563 cites W2028892042 @default.
- W1978493563 cites W2036341177 @default.
- W1978493563 cites W2051101627 @default.
- W1978493563 cites W2053419157 @default.
- W1978493563 cites W2058840869 @default.
- W1978493563 cites W2064192432 @default.
- W1978493563 cites W2065572357 @default.
- W1978493563 cites W2073771651 @default.
- W1978493563 cites W2074250226 @default.
- W1978493563 cites W2091894366 @default.
- W1978493563 cites W2093354837 @default.
- W1978493563 cites W2111920833 @default.
- W1978493563 cites W2126843174 @default.
- W1978493563 cites W2141173013 @default.
- W1978493563 cites W2152914011 @default.
- W1978493563 cites W2157904903 @default.
- W1978493563 doi "https://doi.org/10.1167/iovs.12-10792" @default.
- W1978493563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23425696" @default.
- W1978493563 hasPublicationYear "2013" @default.
- W1978493563 type Work @default.
- W1978493563 sameAs 1978493563 @default.
- W1978493563 citedByCount "1" @default.
- W1978493563 countsByYear W19784935632021 @default.
- W1978493563 crossrefType "journal-article" @default.
- W1978493563 hasAuthorship W1978493563A5017335738 @default.
- W1978493563 hasAuthorship W1978493563A5034055970 @default.
- W1978493563 hasAuthorship W1978493563A5047793069 @default.
- W1978493563 hasAuthorship W1978493563A5061895901 @default.
- W1978493563 hasConcept C105702510 @default.
- W1978493563 hasConcept C141071460 @default.
- W1978493563 hasConcept C142724271 @default.
- W1978493563 hasConcept C2776082946 @default.
- W1978493563 hasConcept C2776805190 @default.
- W1978493563 hasConcept C2779649809 @default.
- W1978493563 hasConcept C2781172350 @default.
- W1978493563 hasConcept C2781302119 @default.
- W1978493563 hasConcept C42219234 @default.
- W1978493563 hasConcept C71924100 @default.
- W1978493563 hasConceptScore W1978493563C105702510 @default.
- W1978493563 hasConceptScore W1978493563C141071460 @default.
- W1978493563 hasConceptScore W1978493563C142724271 @default.
- W1978493563 hasConceptScore W1978493563C2776082946 @default.
- W1978493563 hasConceptScore W1978493563C2776805190 @default.
- W1978493563 hasConceptScore W1978493563C2779649809 @default.
- W1978493563 hasConceptScore W1978493563C2781172350 @default.
- W1978493563 hasConceptScore W1978493563C2781302119 @default.
- W1978493563 hasConceptScore W1978493563C42219234 @default.
- W1978493563 hasConceptScore W1978493563C71924100 @default.
- W1978493563 hasIssue "3" @default.
- W1978493563 hasLocation W19784935631 @default.
- W1978493563 hasLocation W19784935632 @default.
- W1978493563 hasOpenAccess W1978493563 @default.
- W1978493563 hasPrimaryLocation W19784935631 @default.
- W1978493563 hasRelatedWork W1966758897 @default.
- W1978493563 hasRelatedWork W2031284608 @default.
- W1978493563 hasRelatedWork W2039149021 @default.
- W1978493563 hasRelatedWork W2062122799 @default.
- W1978493563 hasRelatedWork W2369300776 @default.
- W1978493563 hasRelatedWork W2384164744 @default.
- W1978493563 hasRelatedWork W2439755323 @default.
- W1978493563 hasRelatedWork W2461051939 @default.
- W1978493563 hasRelatedWork W3208316966 @default.
- W1978493563 hasRelatedWork W41240475 @default.
- W1978493563 hasVolume "54" @default.
- W1978493563 isParatext "false" @default.
- W1978493563 isRetracted "false" @default.
- W1978493563 magId "1978493563" @default.
- W1978493563 workType "article" @default.