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- W1978493949 abstract "We investigated the relative roles of B cell activity, circulating immune complexes, complement concentration and kinetics of disappearance and uptake of immune complexes from the circulation in the pathogenesis of early nephritis of MRL/lpr mice. In comparison to data in control (C57BL/6J) mice, B cell activity was enhanced and the concentration of autoantibodies and endogenous immune complexes in plasma were increased, whereas complement (C3) concentration was not significantly different in MRL/lpr mice. The kinetics of disappearance of radiolabeled immune complexes from the circulation were similar in MRL/lpr and control mice, whereas uptake of radiolabeled immune complexes by the liver was decreased in MRL/lpr mice. Features of polyclonal B cell activation and impaired mononuclear phagocyte function are early events that may set the stage for progressive systemic involvement in MRL/lpr mice." @default.
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- W1978493949 date "1994-01-01" @default.
- W1978493949 modified "2023-10-17" @default.
- W1978493949 title "Pathogenesis of early nephritis in lupus prone mice with a genetic accelerating (lpr) factor" @default.
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- W1978493949 doi "https://doi.org/10.3109/08916939409010654" @default.
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