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• W1978495215 abstract "To investigate whether formocresol, in Buckley's original formulation, used for pulp therapy of deciduous teeth, can have a genotoxic effect. Genotoxicity was tested in lymphocyte cultures from the peripheral blood of children aged 5–10 y, in Recife, Pernambuco, Brazil. This was a case–control study. The sample comprised 40 children who had primary teeth with non-vital pulps. Two venous blood samples (6–8 ml) were collected from each child, the first prior to pulp therapy (control group) and the second 24 h after pulp therapy (experimental group). Lymphocyte cultures were grown in 78% RPMI 1640 medium, 20% fetal bovine serum, 2% phytohemagglutinin. The lymphocytes were assessed for chromosomal aberrations; each sample involved analysis of 100 metaphases. There was a statistically significant difference between the control and treated groups for the isochromatid gap (p < 0.001), chromatid break (p < 0.009), isochromatid break (p < 0.046), other chromosomal alterations (p < 0.001), and for total aberrations. In view of these results, caution in the use of formocresol in pediatric dentistry is recommended." @default.
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• W1978495215 date "2012-08-01" @default.
• W1978495215 modified "2023-10-01" @default.
• W1978495215 title "Genotoxic effect of formocresol pulp therapy of deciduous teeth" @default.
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• W1978495215 doi "https://doi.org/10.1016/j.mrgentox.2012.04.006" @default.
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