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- W1978496412 endingPage "1027" @default.
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- W1978496412 abstract "Introduction: Advanced-stage Hodgkin's lymphoma (HL) has become a curable disease in the majority of patients. Despite this, about 20% of these patients relapsed or are primary refractory to the first-line treatment and high-dose chemotherapy (HDC) and autologous (Auto) hematopoietic progenitor cells transplantation (HPCT) are considered a therapeutic option. Areas covered: The authors reviewed HDC and HPCT treatment strategies in recurrent or refractory HL patients, with the goal of providing an overview of this approach. Expert opinion: Patients younger than 60 – 65 years with relapsed disease or refractory to first-line therapy should receive a second-line chemotherapy, followed by HDC and Auto-HPCT. Progression-free and overall survival results are significantly better when a second remission or a minimal disease status is achieved before Auto-HPCT, and demonstrate that this strategy is able to cure more than half of the advanced HL patients. Myeloablative allogeneic HPCT (Allo-HPCT) has been employed in advanced phases of the disease, but there have been significant concerns due to treatment-related mortality (TRM). The safety of allogeneic transplantation has improved with the use of reduced-intensity allogeneic (RIC-Allo) HPCT strategies. Despite early favorable results, mature results of RIC-Allo available in the literature are consistent in demonstrating a lack of long-term disease control." @default.
- W1978496412 created "2016-06-24" @default.
- W1978496412 creator A5001406717 @default.
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- W1978496412 creator A5067216825 @default.
- W1978496412 creator A5076652491 @default.
- W1978496412 creator A5086116060 @default.
- W1978496412 date "2013-04-16" @default.
- W1978496412 modified "2023-09-27" @default.
- W1978496412 title "Hematopoietic progenitor cells transplantation for recurrent or refractory Hodgkin's lymphoma" @default.
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