FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978498236> ?p ?o ?g. }

• W1978498236 endingPage "1356" @default.
• W1978498236 startingPage "1351" @default.
• W1978498236 abstract "Advances in acute graft-versus-host disease therapy are needed.We examined the efficacy of sirolimus as primary therapy for acute graft-versus-host disease in 32 patients.Acute graft-versus-host disease involved the skin in 53% of cases, gastrointestinal tract in 66%, liver in 16%. The syndrome was overall grade 1 in 12% cases, grade 2 in 75%, and grade 3 in 13%. Sirolimus was targeted to achieve serum trough levels of 5-14 ng/mL. Sixteen (50%) patients achieved sustained, complete resolution of acute graft-versus-host disease with sirolimus alone. In contrast, 19 of 32 (59%) matched historical controls treated with standard 1 mg/kg steroids achieved complete response (P=0.47). With median follow-up time for surviving patients of 16 (range 6-26) months, one year overall survival was 56% (95% CI 38-74%). The cumulative incidence of relapse at one year was 37% (95% CI 23-60%), and mortality in remission was 20% (95% CI 10-42%). The cumulative incidence of chronic graft-versus-host disease was 55% (95% CI 39-79%). Thrombotic microangiopathy occurred in 3 cases (grade 1 n=1; grade 2 n=2), and responded to dose reduction of calcineurin inhibitor.In this retrospective series, sirolimus demonstrates activity comparable to that of high-dose glucocorticoids in the primary therapy of acute graft-versus-host disease. Confirmation of this activity requires prospective clinical trials." @default.
• W1978498236 created "2016-06-24" @default.
• W1978498236 creator A5004386819 @default.
• W1978498236 creator A5010176911 @default.
• W1978498236 creator A5012866839 @default.
• W1978498236 creator A5023535165 @default.
• W1978498236 creator A5035905546 @default.
• W1978498236 creator A5037993855 @default.
• W1978498236 creator A5060783496 @default.
• W1978498236 creator A5062691289 @default.
• W1978498236 creator A5064049791 @default.
• W1978498236 creator A5068862906 @default.
• W1978498236 creator A5083349008 @default.
• W1978498236 creator A5087799564 @default.
• W1978498236 date "2011-05-12" @default.
• W1978498236 modified "2023-10-17" @default.
• W1978498236 title "Sirolimus demonstrates activity in the primary therapy of acute graft-versus-host disease without systemic glucocorticoids" @default.
• W1978498236 cites W1500757144 @default.
• W1978498236 cites W1599864954 @default.
• W1978498236 cites W1965626249 @default.
• W1978498236 cites W1977218446 @default.
• W1978498236 cites W1978635205 @default.
• W1978498236 cites W1988081915 @default.
• W1978498236 cites W1988338260 @default.
• W1978498236 cites W2002577582 @default.
• W1978498236 cites W2044362858 @default.
• W1978498236 cites W2046465273 @default.
• W1978498236 cites W2071394735 @default.
• W1978498236 cites W2073140442 @default.
• W1978498236 cites W2080322619 @default.
• W1978498236 cites W2085290177 @default.
• W1978498236 cites W2090779203 @default.
• W1978498236 cites W2123368042 @default.
• W1978498236 cites W2129128251 @default.
• W1978498236 cites W2139071236 @default.
• W1978498236 cites W2154790810 @default.
• W1978498236 cites W2155616447 @default.
• W1978498236 cites W2157147843 @default.
• W1978498236 cites W2169508471 @default.
• W1978498236 cites W2328760471 @default.
• W1978498236 cites W2980822521 @default.
• W1978498236 doi "https://doi.org/10.3324/haematol.2011.041236" @default.
• W1978498236 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3166106" @default.
• W1978498236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21565902" @default.
• W1978498236 hasPublicationYear "2011" @default.
• W1978498236 type Work @default.
• W1978498236 sameAs 1978498236 @default.
• W1978498236 citedByCount "18" @default.
• W1978498236 countsByYear W19784982362012 @default.
• W1978498236 countsByYear W19784982362013 @default.
• W1978498236 countsByYear W19784982362014 @default.
• W1978498236 countsByYear W19784982362015 @default.
• W1978498236 countsByYear W19784982362016 @default.
• W1978498236 countsByYear W19784982362017 @default.
• W1978498236 countsByYear W19784982362018 @default.
• W1978498236 countsByYear W19784982362020 @default.
• W1978498236 crossrefType "journal-article" @default.
• W1978498236 hasAuthorship W1978498236A5004386819 @default.
• W1978498236 hasAuthorship W1978498236A5010176911 @default.
• W1978498236 hasAuthorship W1978498236A5012866839 @default.
• W1978498236 hasAuthorship W1978498236A5023535165 @default.
• W1978498236 hasAuthorship W1978498236A5035905546 @default.
• W1978498236 hasAuthorship W1978498236A5037993855 @default.
• W1978498236 hasAuthorship W1978498236A5060783496 @default.
• W1978498236 hasAuthorship W1978498236A5062691289 @default.
• W1978498236 hasAuthorship W1978498236A5064049791 @default.
• W1978498236 hasAuthorship W1978498236A5068862906 @default.
• W1978498236 hasAuthorship W1978498236A5083349008 @default.
• W1978498236 hasAuthorship W1978498236A5087799564 @default.
• W1978498236 hasBestOaLocation W19784982361 @default.
• W1978498236 hasConcept C120665830 @default.
• W1978498236 hasConcept C121332964 @default.
• W1978498236 hasConcept C126322002 @default.
• W1978498236 hasConcept C128057223 @default.
• W1978498236 hasConcept C141071460 @default.
• W1978498236 hasConcept C167135981 @default.
• W1978498236 hasConcept C2777921159 @default.
• W1978498236 hasConcept C2779972918 @default.
• W1978498236 hasConcept C2909675724 @default.
• W1978498236 hasConcept C2911091166 @default.
• W1978498236 hasConcept C31785415 @default.
• W1978498236 hasConcept C61511704 @default.
• W1978498236 hasConcept C71924100 @default.
• W1978498236 hasConcept C88879693 @default.
• W1978498236 hasConcept C90924648 @default.
• W1978498236 hasConceptScore W1978498236C120665830 @default.
• W1978498236 hasConceptScore W1978498236C121332964 @default.
• W1978498236 hasConceptScore W1978498236C126322002 @default.
• W1978498236 hasConceptScore W1978498236C128057223 @default.
• W1978498236 hasConceptScore W1978498236C141071460 @default.
• W1978498236 hasConceptScore W1978498236C167135981 @default.
• W1978498236 hasConceptScore W1978498236C2777921159 @default.
• W1978498236 hasConceptScore W1978498236C2779972918 @default.
• W1978498236 hasConceptScore W1978498236C2909675724 @default.
• W1978498236 hasConceptScore W1978498236C2911091166 @default.
• W1978498236 hasConceptScore W1978498236C31785415 @default.
• W1978498236 hasConceptScore W1978498236C61511704 @default.
• W1978498236 hasConceptScore W1978498236C71924100 @default.

• next