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- W1978501871 abstract "The search for reliable early indicators of age-related cognitive decline represents a critical avenue for progress in aging research. Chronological age is a commonly used developmental index; however, it offers little insight into the mechanisms underlying cognitive decline. In contrast, biological age (BioAge), reflecting the vitality of essential biological systems, represents a promising operationalization of developmental time. Current BioAge models have successfully predicted age-related cognitive deficits. Research on aging-related cognitive function indicates that the interaction of multiple risk and protective factors across the human lifespan confers individual risk for late-life cognitive decline, implicating a multi-causal explanation. In this review, we explore current BioAge models, describe three broad yet pathologically relevant biological processes linked to cognitive decline, and propose a novel operationalization of BioAge accounting for both moderating and causal mechanisms of cognitive decline and dementia. We argue that a multivariate and mechanistic BioAge approach will lead to a greater understanding of disease pathology as well as more accurate prediction and early identification of late-life cognitive decline." @default.
- W1978501871 created "2016-06-24" @default.
- W1978501871 creator A5031815065 @default.
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- W1978501871 creator A5067045341 @default.
- W1978501871 creator A5089277137 @default.
- W1978501871 creator A5091895732 @default.
- W1978501871 date "2014-11-01" @default.
- W1978501871 modified "2023-09-26" @default.
- W1978501871 title "BioAge: Toward a multi-determined, mechanistic account of cognitive aging" @default.
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