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- W1978503286 abstract "Diphenylhydantoin (Dilantin) has been used extensively as anticonvulsant therapy since its introduction in 1938, as has phenobarbital since 1912. It was not until 1952 that Mannheimer et al. 1 described leukopenia and megaloblastic anemia in an epileptic patient being treated with diphenylhydantoin. After the administration of cyanocobalamin (vitamin B 12 ) the blood gradually returned to normal. Badenoch 2 in 1954 was the first to suggest a causal relationship between megaloblastic anemia and anticonvulsant medication in two case reports. Diphenylhydantoin, primidone (Mysoline), and barbiturates either singly or in combination have been shown capable of inducing megaloblastic anemia. The purpose of this report is to describe a case of megaloblastic anemia associated with diphenylhydantoin and phenobarbital therapy and to review the literature on this subject. Report of Case A 50-year-old white woman entered St. Vincent's Hospital for the first time on Dec. 7, 1961, because of increasing weakness and shortness of breath" @default.
- W1978503286 created "2016-06-24" @default.
- W1978503286 creator A5016848758 @default.
- W1978503286 date "1963-06-01" @default.
- W1978503286 modified "2023-09-25" @default.
- W1978503286 title "Megaloblastic Anemia During Anticonvulsant Drug Therapy" @default.
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- W1978503286 doi "https://doi.org/10.1001/archinte.1963.03620300064011" @default.
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