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• W1978504482 abstract "The effect of the skin tumor-promoter TPA (12-O-tetradecanoylphorbol-13-ace-tate) on expression of cellular proto-oncogenes has been examined in cell lines derived from human urothelium. A single treatment with TPA (1 μg/ml) increased the transcription of c-fos and c-myc proto-oncogenes at least 20-fold in the mortal cell line HU 1752. The induction was transient and was accompanied by a rapid but transient change in cell morphology. When immortalized cell lines were treated with TPA a similar rapid and transient morphological response was observed, but the TPA treatment only increased the level of c-fos mRNA. suggesting that the normal regulation of c-myc transcription is altered in immortalized cells irrespective of their tumorigenic properties. The levels of c-Ha-ras and c-Ki-ras mRNAs were unaffected by TPA treatment in all cell lines." @default.
• W1978504482 created "2016-06-24" @default.
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• W1978504482 date "1987-06-01" @default.
• W1978504482 modified "2023-09-25" @default.
• W1978504482 title "Differential induction of transcription of c-myc and c-fos proto-oncogenes by 12-O-tetradecanoylphorbol-13-acetate in mortal and immortal human-urothelial cells" @default.
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• W1978504482 doi "https://doi.org/10.1002/jcb.240340202" @default.
• W1978504482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3597558" @default.
• W1978504482 hasPublicationYear "1987" @default.
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