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• W1978507399 abstract "Mutations in the gene encoding dystrophin, a large cytoskeletal protein in muscle, lead to Duchenne muscular dystrophy (DMD). Affected individuals often die of respiratory failure resulting primarily from diaphragm muscle degeneration. Here we report a new procedure to transfer the full-length dystrophin cDNA into the diaphragm muscle of Dmdmdx/mdx mice, which carry a mutation in the dystrophin gene (Dmd). Significant gene transfer was found after intravenous injection of naked plasmid DNA followed by a brief (eight second) occlusion of blood flow at the vena cava. This is the first demonstration of gene transfer into the diaphragm muscle through systemic administration of naked plasmid DNA. The approach has potential application for treatment of DMD." @default.
• W1978507399 created "2016-06-24" @default.
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• W1978507399 date "2001-07-01" @default.
• W1978507399 modified "2023-10-12" @default.
• W1978507399 title "Transfer of Full-Length Dmd to the Diaphragm Muscle of Dmdmdx/mdx Mice through Systemic Administration of Plasmid DNA" @default.
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• W1978507399 doi "https://doi.org/10.1006/mthe.2001.0419" @default.
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