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- W1978507952 abstract "A major challenge in cancer treatment is the development of therapies that target cancer cells with little or no toxicity to normal tissues and cells. Alterations in DNA double strand break (DSB) repair in cancer cells include both elevated and reduced levels of key repair proteins and changes in the relative contributions of the various DSB repair pathways. These differences can result in increased sensitivity to DSB-inducing agents and increased genomic instability. The development of agents that selectively inhibit the DSB repair pathways that cancer cells are more dependent upon will facilitate the design of therapeutic strategies that exploit the differences in DSB repair between normal and cancer cells. Here, we discuss the pathways of DSB repair, alterations in DSB repair in cancer, inhibitors of DSB repair and future directions for cancer therapies that target DSB repair." @default.
- W1978507952 created "2016-06-24" @default.
- W1978507952 creator A5045398774 @default.
- W1978507952 creator A5051816777 @default.
- W1978507952 date "2010-08-10" @default.
- W1978507952 modified "2023-10-07" @default.
- W1978507952 title "Targeting abnormal DNA double strand break repair in cancer" @default.
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