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- W1978508559 abstract "A systematic study of the role of the Ca2+ and Mn2+ ions on the interaction between heparin and Concanavalin A was carried out. The protein was demetallized, and complex formation was followed by a light scattering assay. In the absence of ions no visible interaction was detected. Maximum activity was obtained when Mn2+ ions were added. A similar effect was observed when Ca2+ ions alone were used. Kinetics of the interaction in the presence of optimal Mn2+ and(or) Ca2+ concentrations confirmed the role of Ca2+ in accelerating a conformational change leading to a functional protein. A peculiar effect of activation-inhibition depending on ion concentration was also exhibited by Ca2+. These results confirm that Ca2+ and Mn2+ can occupy both sites on Concanavalin A and activate the protein for binding heparin. They point also to a crucial role of Ca2+ in the binding capacity of the active heparin fraction." @default.
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- W1978508559 date "1989-05-01" @default.
- W1978508559 modified "2023-10-18" @default.
- W1978508559 title "Heparin and concanavalin A interaction as a model for studying the mechanism of the anticoagulant activity" @default.
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- W1978508559 doi "https://doi.org/10.1016/0049-3848(89)90231-4" @default.
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