Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978511169> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1978511169 endingPage "1158" @default.
- W1978511169 startingPage "1156" @default.
- W1978511169 abstract "Objective In trials of chronic disease therapy, each patient may experience several nonfatal illnesses and death. “Composite” outcome measures combine information from these different components of disease burden. Most common is the binary distinction between patients undergoing one or more events and those undergoing no events. We compare this approach with a composite score that preserves information on the number and severity of events. Study Design and Setting The binary composite measure and composite score were derived for each patient in a trial of cardiovascular therapy. All nonfatal events contributed to the composite score according to their severity: recurrent myocardial infarction (weight 0.5), congestive heart failure that required the use of open-label angiotensin-converting enzyme (ACE) inhibitors (weight 0.2), and hospitalization to treat congestive heart failure (weight 0.5). Results In the example data set, the composite score required a 10% larger sample size to achieve the same power as the binary measure. However, the composite score suggested that the treatment impacted on the first nonfatal event and mortality only. Conclusions The composite score provides a more informative measure of disease burden and may avoid overestimating the evidence supporting a treatment effect when that evidence is largely from less severe early events." @default.
- W1978511169 created "2016-06-24" @default.
- W1978511169 creator A5031560506 @default.
- W1978511169 creator A5047824675 @default.
- W1978511169 creator A5049632527 @default.
- W1978511169 creator A5054830306 @default.
- W1978511169 creator A5078250568 @default.
- W1978511169 date "2010-10-01" @default.
- W1978511169 modified "2023-09-24" @default.
- W1978511169 title "Composite outcomes: weighting component events according to severity assisted interpretation but reduced statistical power" @default.
- W1978511169 cites W1980903642 @default.
- W1978511169 cites W2001096404 @default.
- W1978511169 cites W2002206387 @default.
- W1978511169 cites W2035882325 @default.
- W1978511169 cites W2051837586 @default.
- W1978511169 cites W2089753305 @default.
- W1978511169 cites W2136068942 @default.
- W1978511169 cites W2146356766 @default.
- W1978511169 cites W2160784493 @default.
- W1978511169 cites W2167988219 @default.
- W1978511169 cites W2312388685 @default.
- W1978511169 cites W2911987067 @default.
- W1978511169 doi "https://doi.org/10.1016/j.jclinepi.2010.01.019" @default.
- W1978511169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20558037" @default.
- W1978511169 hasPublicationYear "2010" @default.
- W1978511169 type Work @default.
- W1978511169 sameAs 1978511169 @default.
- W1978511169 citedByCount "15" @default.
- W1978511169 countsByYear W19785111692013 @default.
- W1978511169 countsByYear W19785111692016 @default.
- W1978511169 countsByYear W19785111692017 @default.
- W1978511169 countsByYear W19785111692018 @default.
- W1978511169 countsByYear W19785111692019 @default.
- W1978511169 countsByYear W19785111692020 @default.
- W1978511169 countsByYear W19785111692021 @default.
- W1978511169 crossrefType "journal-article" @default.
- W1978511169 hasAuthorship W1978511169A5031560506 @default.
- W1978511169 hasAuthorship W1978511169A5047824675 @default.
- W1978511169 hasAuthorship W1978511169A5049632527 @default.
- W1978511169 hasAuthorship W1978511169A5054830306 @default.
- W1978511169 hasAuthorship W1978511169A5078250568 @default.
- W1978511169 hasConcept C126322002 @default.
- W1978511169 hasConcept C126838900 @default.
- W1978511169 hasConcept C183115368 @default.
- W1978511169 hasConcept C1862650 @default.
- W1978511169 hasConcept C2778198053 @default.
- W1978511169 hasConcept C500558357 @default.
- W1978511169 hasConcept C535046627 @default.
- W1978511169 hasConcept C71924100 @default.
- W1978511169 hasConceptScore W1978511169C126322002 @default.
- W1978511169 hasConceptScore W1978511169C126838900 @default.
- W1978511169 hasConceptScore W1978511169C183115368 @default.
- W1978511169 hasConceptScore W1978511169C1862650 @default.
- W1978511169 hasConceptScore W1978511169C2778198053 @default.
- W1978511169 hasConceptScore W1978511169C500558357 @default.
- W1978511169 hasConceptScore W1978511169C535046627 @default.
- W1978511169 hasConceptScore W1978511169C71924100 @default.
- W1978511169 hasIssue "10" @default.
- W1978511169 hasLocation W19785111691 @default.
- W1978511169 hasLocation W19785111692 @default.
- W1978511169 hasOpenAccess W1978511169 @default.
- W1978511169 hasPrimaryLocation W19785111691 @default.
- W1978511169 hasRelatedWork W2119852139 @default.
- W1978511169 hasRelatedWork W2165119695 @default.
- W1978511169 hasRelatedWork W2316107365 @default.
- W1978511169 hasRelatedWork W2367140913 @default.
- W1978511169 hasRelatedWork W2377483921 @default.
- W1978511169 hasRelatedWork W2384102316 @default.
- W1978511169 hasRelatedWork W2411183214 @default.
- W1978511169 hasRelatedWork W2443697580 @default.
- W1978511169 hasRelatedWork W2595649087 @default.
- W1978511169 hasRelatedWork W4247718175 @default.
- W1978511169 hasVolume "63" @default.
- W1978511169 isParatext "false" @default.
- W1978511169 isRetracted "false" @default.
- W1978511169 magId "1978511169" @default.
- W1978511169 workType "article" @default.