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- W1978511926 abstract "The primary function of synaptic vesicles is to store and release neurotransmitter. Synaptic vesicles are locally recycled following exocytosis and rapidly refilled with neurotransmitter from the cytoplasm by a process that depends on the electrochemical gradient generated by a proton pump. Little is known about the molecules that import neurotransmitter into synaptic vesicles. We report here that the sequence of the synaptic vesicle protein SV2 identifies this protein as a novel type of transmembrane transporter. The deduced amino acid sequence of SV2 contains two sets of six predicted transmembrane domains: the six most N-terminal transmembrane domains are highly homologous to a subfamily of transporters that includes the human glucose transporter, while the six most C-terminal domains are homologous to the plasma membrane transporters for neurotransmitters. We propose that SV2 mediates transport of neurotransmitters into synaptic vesicles." @default.
- W1978511926 created "2016-06-24" @default.
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- W1978511926 date "1992-09-01" @default.
- W1978511926 modified "2023-10-11" @default.
- W1978511926 title "The synaptic vesicle protein SV2 is a novel type of transmembrane transporter" @default.
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- W1978511926 doi "https://doi.org/10.1016/0092-8674(92)90319-8" @default.
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