FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978516907> ?p ?o ?g. }

• W1978516907 abstract "Abstract Background Human influenza viruses are known to bind to sialic acid linked α2-6 to galactose, but the binding specificity beyond that linkage has not been systematically examined. H3N2 human influenza isolates lost binding to chicken red cells in the 1990s but viruses isolated since 2003 have re-acquired the ability to agglutinate chicken erythrocytes. We have investigated specificity of binding, changes in hemagglutinin sequence of the recent viruses and the role of sialic acid in productive infection. Results Viruses that agglutinate, or do not agglutinate, chicken red cells show identical binding to a Glycan Array of 264 oligosaccharides, binding exclusively to a subset of α2-6-sialylsaccharides. We identified an amino acid change in hemagglutinin that seemed to correlate with chicken red cell binding but when tested by mutagenesis there was no effect. Recombinant hemagglutinins expressed on Sf-9 cells bound chicken red cells but the released recombinant baculoviruses agglutinated only human red cells. Similarly, an isolate that does not agglutinate chicken red cells show hemadsorption of chicken red cells to infected MDCK cells. We suggest that binding of chicken red cells to cell surface hemagglutinin but not to virions is due to a more favorable hemagglutinin density on the cell surface. We investigated whether a virus specific for α2-6 sialyloligosaccharides shows differential entry into cells that have varying proportions of α2-6 and α2-3 sialic acids, including human A549 and HeLa cells with high levels of α2-6 sialic acid, and CHO cells that have only α2-3 sialic acid. We found that the virus enters all cell types tested and synthesizes viral nucleoprotein, localized in the nucleus, and hemagglutinin, transported to the cell surface, but infectious progeny viruses were released only from MDCK cells. Conclusion Agglutination of chicken red cells does not correlate with altered binding to any oligosaccharide on the Glycan Array, and may result from increased avidity due to density of hemagglutinin and not increased affinity. Absence of α2-6 sialic acid does not protect a cell from influenza infection and the presence of high levels of α2-6-sialic acids on a cell surface does not guarantee productive replication of a virus with α2-6 receptor specificity." @default.
• W1978516907 created "2016-06-24" @default.
• W1978516907 creator A5018976800 @default.
• W1978516907 creator A5019324038 @default.
• W1978516907 creator A5023341393 @default.
• W1978516907 creator A5041917354 @default.
• W1978516907 creator A5074899500 @default.
• W1978516907 creator A5083316340 @default.
• W1978516907 date "2007-05-09" @default.
• W1978516907 modified "2023-10-02" @default.
• W1978516907 title "Receptor binding specificity of recent human H3N2 influenza viruses" @default.
• W1978516907 cites W1514815542 @default.
• W1978516907 cites W1516179737 @default.
• W1978516907 cites W1524983665 @default.
• W1978516907 cites W1529118467 @default.
• W1978516907 cites W1966525809 @default.
• W1978516907 cites W1967338600 @default.
• W1978516907 cites W1977548126 @default.
• W1978516907 cites W1977554521 @default.
• W1978516907 cites W1979110745 @default.
• W1978516907 cites W1997331643 @default.
• W1978516907 cites W1998561673 @default.
• W1978516907 cites W2015357217 @default.
• W1978516907 cites W2020540463 @default.
• W1978516907 cites W2026391844 @default.
• W1978516907 cites W2035088373 @default.
• W1978516907 cites W2039523393 @default.
• W1978516907 cites W2041122748 @default.
• W1978516907 cites W2044220196 @default.
• W1978516907 cites W2046056601 @default.
• W1978516907 cites W2050586107 @default.
• W1978516907 cites W2052330831 @default.
• W1978516907 cites W2053433452 @default.
• W1978516907 cites W2054604776 @default.
• W1978516907 cites W2056597222 @default.
• W1978516907 cites W2059123752 @default.
• W1978516907 cites W2061734037 @default.
• W1978516907 cites W2066218699 @default.
• W1978516907 cites W2066252710 @default.
• W1978516907 cites W2066635664 @default.
• W1978516907 cites W2067458777 @default.
• W1978516907 cites W2075737064 @default.
• W1978516907 cites W2077095962 @default.
• W1978516907 cites W2080929418 @default.
• W1978516907 cites W2082030984 @default.
• W1978516907 cites W2084466479 @default.
• W1978516907 cites W2098429501 @default.
• W1978516907 cites W2113262676 @default.
• W1978516907 cites W2115496163 @default.
• W1978516907 cites W2123546614 @default.
• W1978516907 cites W2125739732 @default.
• W1978516907 cites W2125782486 @default.
• W1978516907 cites W2131492616 @default.
• W1978516907 cites W2132527856 @default.
• W1978516907 cites W2140474433 @default.
• W1978516907 cites W2149806036 @default.
• W1978516907 cites W2153782171 @default.
• W1978516907 cites W2158616404 @default.
• W1978516907 cites W2164010846 @default.
• W1978516907 cites W2171369029 @default.
• W1978516907 cites W2171863940 @default.
• W1978516907 cites W2183175522 @default.
• W1978516907 cites W2470439338 @default.
• W1978516907 cites W4313335776 @default.
• W1978516907 doi "https://doi.org/10.1186/1743-422x-4-42" @default.
• W1978516907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1876801" @default.
• W1978516907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17490484" @default.
• W1978516907 hasPublicationYear "2007" @default.
• W1978516907 type Work @default.
• W1978516907 sameAs 1978516907 @default.
• W1978516907 citedByCount "150" @default.
• W1978516907 countsByYear W19785169072012 @default.
• W1978516907 countsByYear W19785169072013 @default.
• W1978516907 countsByYear W19785169072014 @default.
• W1978516907 countsByYear W19785169072015 @default.
• W1978516907 countsByYear W19785169072016 @default.
• W1978516907 countsByYear W19785169072017 @default.
• W1978516907 countsByYear W19785169072018 @default.
• W1978516907 countsByYear W19785169072019 @default.
• W1978516907 countsByYear W19785169072020 @default.
• W1978516907 countsByYear W19785169072021 @default.
• W1978516907 countsByYear W19785169072022 @default.
• W1978516907 countsByYear W19785169072023 @default.
• W1978516907 crossrefType "journal-article" @default.
• W1978516907 hasAuthorship W1978516907A5018976800 @default.
• W1978516907 hasAuthorship W1978516907A5019324038 @default.
• W1978516907 hasAuthorship W1978516907A5023341393 @default.
• W1978516907 hasAuthorship W1978516907A5041917354 @default.
• W1978516907 hasAuthorship W1978516907A5074899500 @default.
• W1978516907 hasAuthorship W1978516907A5083316340 @default.
• W1978516907 hasBestOaLocation W19785169071 @default.
• W1978516907 hasConcept C104317684 @default.
• W1978516907 hasConcept C108625454 @default.
• W1978516907 hasConcept C153911025 @default.
• W1978516907 hasConcept C159047783 @default.
• W1978516907 hasConcept C206212055 @default.
• W1978516907 hasConcept C2522874641 @default.
• W1978516907 hasConcept C2777546802 @default.
• W1978516907 hasConcept C2778671442 @default.
• W1978516907 hasConcept C2778692840 @default.

• next