FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978522055> ?p ?o ?g. }

• W1978522055 endingPage "104" @default.
• W1978522055 startingPage "89" @default.
• W1978522055 abstract "The progression of epileptiform activity following soman (GD) exposure is characterized by a period of excessive cholinergic activity followed by excessive glutamatergic activity resulting in status epilepticus, which may lead to neuropathological damage and behavioral deficits. Caramiphen edisylate is an anticholinergic drug with antiglutamatergic properties, which conceptually may be a beneficial therapeutic approach to the treatment of nerve agent exposure. In the present study, rats were exposed to 1.2 LD50 GD or saline, treated with atropine sulfate (2 mg/kg, im) and HI-6 (93.6 mg/kg, im) 1 min after GD exposure, and monitored for seizure activity. Rats were treated with diazepam (10 mg/kg, sc) and caramiphen (0, 20 or 100 mg/kg, im) 30 min after seizure onset. Following GD exposure, performance was evaluated using a battery of behavioral tests to assess motor coordination and function, sensorimotor gating, and cognitive function. Caramiphen as adjunct to diazepam treatment attenuated GD-induced seizure activity, neuropathological damage, and cognitive deficits compared to diazepam alone, but did not attenuate the GD-induced sensorimotor gating impairment. These findings show that physiological, behavioral, and neuropathological effects of GD exposure can be attenuated by treatment with caramiphen as an adjunct to therapy, even if administration is delayed to 30 min after seizure onset." @default.
• W1978522055 created "2016-06-24" @default.
• W1978522055 creator A5029244307 @default.
• W1978522055 creator A5035121433 @default.
• W1978522055 creator A5039314139 @default.
• W1978522055 creator A5040605302 @default.
• W1978522055 creator A5048330858 @default.
• W1978522055 creator A5049743823 @default.
• W1978522055 creator A5054612189 @default.
• W1978522055 creator A5062286278 @default.
• W1978522055 creator A5077112837 @default.
• W1978522055 creator A5080094794 @default.
• W1978522055 creator A5086125637 @default.
• W1978522055 date "2014-07-01" @default.
• W1978522055 modified "2023-10-11" @default.
• W1978522055 title "Caramiphen edisylate as adjunct to standard therapy attenuates soman-induced seizures and cognitive deficits in rats" @default.
• W1978522055 cites W1489003835 @default.
• W1978522055 cites W1502258650 @default.
• W1978522055 cites W1567909332 @default.
• W1978522055 cites W1965134629 @default.
• W1978522055 cites W1969047674 @default.
• W1978522055 cites W1988530810 @default.
• W1978522055 cites W1992160232 @default.
• W1978522055 cites W1995722621 @default.
• W1978522055 cites W2005547796 @default.
• W1978522055 cites W2008326600 @default.
• W1978522055 cites W2009277684 @default.
• W1978522055 cites W2011523571 @default.
• W1978522055 cites W2017566530 @default.
• W1978522055 cites W2019110619 @default.
• W1978522055 cites W2022635879 @default.
• W1978522055 cites W2025619082 @default.
• W1978522055 cites W2027331664 @default.
• W1978522055 cites W2029095821 @default.
• W1978522055 cites W2030536093 @default.
• W1978522055 cites W2040637065 @default.
• W1978522055 cites W2047615712 @default.
• W1978522055 cites W2052072990 @default.
• W1978522055 cites W2052940264 @default.
• W1978522055 cites W2053562287 @default.
• W1978522055 cites W2059913756 @default.
• W1978522055 cites W2066731397 @default.
• W1978522055 cites W2066857662 @default.
• W1978522055 cites W2071644440 @default.
• W1978522055 cites W2088501274 @default.
• W1978522055 cites W2089061301 @default.
• W1978522055 cites W2089927455 @default.
• W1978522055 cites W2090603234 @default.
• W1978522055 cites W2094074393 @default.
• W1978522055 cites W2095822972 @default.
• W1978522055 cites W2096428903 @default.
• W1978522055 cites W2103433759 @default.
• W1978522055 cites W2103509757 @default.
• W1978522055 cites W2103946141 @default.
• W1978522055 cites W2114532083 @default.
• W1978522055 cites W2119480650 @default.
• W1978522055 cites W2126499448 @default.
• W1978522055 cites W2142629193 @default.
• W1978522055 cites W2156203011 @default.
• W1978522055 cites W2156806480 @default.
• W1978522055 cites W2160643155 @default.
• W1978522055 cites W2205439823 @default.
• W1978522055 doi "https://doi.org/10.1016/j.ntt.2014.06.002" @default.
• W1978522055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24946037" @default.
• W1978522055 hasPublicationYear "2014" @default.
• W1978522055 type Work @default.
• W1978522055 sameAs 1978522055 @default.
• W1978522055 citedByCount "37" @default.
• W1978522055 countsByYear W19785220552014 @default.
• W1978522055 countsByYear W19785220552015 @default.
• W1978522055 countsByYear W19785220552016 @default.
• W1978522055 countsByYear W19785220552017 @default.
• W1978522055 countsByYear W19785220552018 @default.
• W1978522055 countsByYear W19785220552019 @default.
• W1978522055 countsByYear W19785220552020 @default.
• W1978522055 countsByYear W19785220552021 @default.
• W1978522055 countsByYear W19785220552022 @default.
• W1978522055 countsByYear W19785220552023 @default.
• W1978522055 crossrefType "journal-article" @default.
• W1978522055 hasAuthorship W1978522055A5029244307 @default.
• W1978522055 hasAuthorship W1978522055A5035121433 @default.
• W1978522055 hasAuthorship W1978522055A5039314139 @default.
• W1978522055 hasAuthorship W1978522055A5040605302 @default.
• W1978522055 hasAuthorship W1978522055A5048330858 @default.
• W1978522055 hasAuthorship W1978522055A5049743823 @default.
• W1978522055 hasAuthorship W1978522055A5054612189 @default.
• W1978522055 hasAuthorship W1978522055A5062286278 @default.
• W1978522055 hasAuthorship W1978522055A5077112837 @default.
• W1978522055 hasAuthorship W1978522055A5080094794 @default.
• W1978522055 hasAuthorship W1978522055A5086125637 @default.
• W1978522055 hasConcept C126322002 @default.
• W1978522055 hasConcept C15744967 @default.
• W1978522055 hasConcept C169760540 @default.
• W1978522055 hasConcept C181199279 @default.
• W1978522055 hasConcept C185592680 @default.
• W1978522055 hasConcept C22885893 @default.
• W1978522055 hasConcept C2775858608 @default.
• W1978522055 hasConcept C2776175493 @default.

• next