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• W1978522079 abstract "In Brief Purpose: To report persistent unilateral flap edema following laser in situ keratomileusis (LASIK) in patients with asymmetrical central corneal thickness. Setting: Minnesota Eye Consultants, Minneapolis, Minnesota. Methods: Retrospective, noncomparative interventional case series. Results: We examined 6 eyes of 3 patients with asymmetrical preoperative pachymetry who developed persistent unilateral flap edema after uneventful myopic LASIK in the eye with thicker preoperative pachymetry. All cases had asymmetrical preoperative pachymetry with flap edema developing in the eye with higher preoperative mean central corneal thickness (CCT) values, preoperative mean CCT subject eye 622 μm (range 556–664 μm) versus fellow eye 583 μm (range 510–621 μm). There was no associated ocular inflammation or rise in intraocular pressure. Significant flap edema resolved on a combination treatment of topical steroid and hypertonic saline. Conclusions: Laser in situ keratomileusis can cause temporary endothelial cell dysfunction or stress, which manifests as temporary flap edema and subclinical corneal thickening. The edema appears to be limited to the actual flap and there was no loss of epithelial integrity in these eyes and no clinically noticeable interface fluid. This new clinical entity appears to occur in patients with asymmetrical preoperative corneal pachymetry and is associated with postoperative specular microscopy abnormalities. In cases with unexplained asymmetrical corneal thickness, preoperative evaluation should include specular microscopy to evaluate for risk features that may increase the chances of a slower postoperative recovery. Unilateral flap edema with slow visual recovery may occur following LASIK in patients with asymmetrical preoperative central corneal thickness. Specular microscopy should be considered in patients with significant differences in preoperative pachymetry values between the 2 eyes." @default.
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• W1978522079 date "2005-05-01" @default.
• W1978522079 modified "2023-09-27" @default.
• W1978522079 title "Noninflammatory flap edema after laser in situ keratomileusis associated with asymmetrical preoperative corneal pachymetry" @default.
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• W1978522079 doi "https://doi.org/10.1016/j.jcrs.2004.08.058" @default.
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