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- W1978525834 endingPage "5167" @default.
- W1978525834 startingPage "5148" @default.
- W1978525834 abstract "The Notch signaling pathway regulates a diverse array of cell types and cellular processes and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands have been identified that may account for some of the pleiotropic nature associated with Notch signaling. This review focuses on the molecular mechanisms by which Notch ligands function as signaling agonists and antagonists, and discusses different modes of activating ligands as well as findings that support intrinsic ligand signaling activity independent of Notch. Post-translational modification, proteolytic processing, endocytosis and membrane trafficking, as well as interactions with the actin cytoskeleton may contribute to the recently appreciated multifunctionality of Notch ligands. The regulation of Notch ligand expression by other signaling pathways provides a mechanism to coordinate Notch signaling with multiple cellular and developmental cues. The association of Notch ligands with inherited human disorders and cancer highlights the importance of understanding the molecular nature and activities intrinsic to Notch ligands." @default.
- W1978525834 created "2016-06-24" @default.
- W1978525834 creator A5005916404 @default.
- W1978525834 creator A5077285682 @default.
- W1978525834 creator A5080777821 @default.
- W1978525834 date "2008-09-01" @default.
- W1978525834 modified "2023-10-10" @default.
- W1978525834 title "The many facets of Notch ligands" @default.
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