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- W1978530217 abstract "The discovery of IL-33 as the ligand for the orphan Th2 associated receptor ST2 has uncovered a whole range of different avenues for this pathway. Although the extracellular functions of ST2 as a marker for Th2 cell and mast cell activity were well defined, the complexities of IL-33 regulation, nuclear function and secretion are only just being realised. The well documented expression pattern of ST2 has identified a role for the IL-33/ST2 axis in the classical Th2 cell and mast cell driven pathogenesis of asthma and anaphylaxis. However, the induction of IL-33 expression by environmental or endogenous triggers now suggests a wider role for the pathway during infection, inflammation and tissue damage." @default.
- W1978530217 created "2016-06-24" @default.
- W1978530217 creator A5073340353 @default.
- W1978530217 date "2010-12-01" @default.
- W1978530217 modified "2023-09-23" @default.
- W1978530217 title "IL-33 family members and asthma – bridging innate and adaptive immune responses" @default.
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- W1978530217 doi "https://doi.org/10.1016/j.coi.2010.10.006" @default.
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