Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978534013> ?p ?o ?g. }
- W1978534013 endingPage "1070" @default.
- W1978534013 startingPage "1061" @default.
- W1978534013 abstract "Summary 1. The present study investigated the ability of trimetazidine (TMZ) to maintain cardiac mitochondrial function during the development of insulin deficiency and hyperinsulinaemia. The anti‐ischaemic drug TMZ is known to increase phospholipid synthesis in cardiac membranes and to have a cardioprotective effect. 2. Insulin deficiency was obtained by streptozotocin injection and hyperinsulinaemia was achieved via a fructose diet. Trimetazidine was incorporated into the diet (7.8 mg/day) and mitochondrial function was evaluated in skinned cardiac fibres. 3. Insulin deficiency decreased mitochondrial affinity for ADP and the index of creatine kinase functional activity. This last alteration was partially prevented by TMZ treatment. Insulin deficiency strongly decreased n‐3 polyunsaturated fatty acids, especially the docosahexaenoic acid (DHA) content, in cardiac and mitochondrial membranes, inducing a strong increase in the n‐6/n‐3 ratio. Trimetazidine treatment limited the increase in the n‐6/n‐3 ratio and prevented the decrease in DHA content in mitochondrial membranes. Insulin deficiency decreased glutamate‐ and palmitoylcarnitine‐supported respiration. 4. Hyperinsulinaemia affected neither mitochondrial affinity for ADP nor the index of creatine kinase functional activity. Hyperinsulinaemia slightly and significantly affected mitochondrial fatty acid composition, by a small increase the n‐6/n‐3 ratio. Trimetazidine did not modify membrane‐bound mitochondrial function but increased the n‐6/n‐3 ratio. Moreover, hyperinsulinaemia decreased glutamate‐supported respiration. 5. In conclusion, modification of membrane homeostasis with TMZ partially prevented the alterations in fatty acid composition and function in cardiac mitochondria induced by insulin deficiency. Three months of hyperinsulinaemia did not modify membrane‐bound mitochondrial function and had only slight effects on fatty acid composition." @default.
- W1978534013 created "2016-06-24" @default.
- W1978534013 creator A5011140662 @default.
- W1978534013 creator A5057748104 @default.
- W1978534013 creator A5084251667 @default.
- W1978534013 date "2005-12-01" @default.
- W1978534013 modified "2023-10-14" @default.
- W1978534013 title "Cardiac mitochondrial alterations induced by insulin deficiency and hyperinsulinaemia in rats: Targeting membrane homeostasis with trimetazidine" @default.
- W1978534013 cites W1507233443 @default.
- W1978534013 cites W1532082124 @default.
- W1978534013 cites W1560423324 @default.
- W1978534013 cites W1572887479 @default.
- W1978534013 cites W1760999968 @default.
- W1978534013 cites W1899340039 @default.
- W1978534013 cites W1970131778 @default.
- W1978534013 cites W1971303004 @default.
- W1978534013 cites W1983090416 @default.
- W1978534013 cites W1988335802 @default.
- W1978534013 cites W1991264488 @default.
- W1978534013 cites W1991385182 @default.
- W1978534013 cites W1995450996 @default.
- W1978534013 cites W2005986814 @default.
- W1978534013 cites W2007683617 @default.
- W1978534013 cites W2008437352 @default.
- W1978534013 cites W2012514868 @default.
- W1978534013 cites W2013853567 @default.
- W1978534013 cites W2018628370 @default.
- W1978534013 cites W2021172172 @default.
- W1978534013 cites W2021871393 @default.
- W1978534013 cites W2022848101 @default.
- W1978534013 cites W2034790550 @default.
- W1978534013 cites W2036447970 @default.
- W1978534013 cites W2045627709 @default.
- W1978534013 cites W2045800623 @default.
- W1978534013 cites W2078559544 @default.
- W1978534013 cites W2079852932 @default.
- W1978534013 cites W2092026589 @default.
- W1978534013 cites W2093418092 @default.
- W1978534013 cites W2100899846 @default.
- W1978534013 cites W2102563922 @default.
- W1978534013 cites W2103422094 @default.
- W1978534013 cites W2120419980 @default.
- W1978534013 cites W2146823800 @default.
- W1978534013 cites W2156357511 @default.
- W1978534013 cites W2165337066 @default.
- W1978534013 cites W2167196393 @default.
- W1978534013 cites W2168526937 @default.
- W1978534013 cites W2192223169 @default.
- W1978534013 cites W2234545529 @default.
- W1978534013 cites W4239842460 @default.
- W1978534013 doi "https://doi.org/10.1111/j.1440-1681.2005.04293.x" @default.
- W1978534013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16445572" @default.
- W1978534013 hasPublicationYear "2005" @default.
- W1978534013 type Work @default.
- W1978534013 sameAs 1978534013 @default.
- W1978534013 citedByCount "11" @default.
- W1978534013 countsByYear W19785340132012 @default.
- W1978534013 countsByYear W19785340132014 @default.
- W1978534013 countsByYear W19785340132015 @default.
- W1978534013 countsByYear W19785340132016 @default.
- W1978534013 countsByYear W19785340132019 @default.
- W1978534013 countsByYear W19785340132021 @default.
- W1978534013 crossrefType "journal-article" @default.
- W1978534013 hasAuthorship W1978534013A5011140662 @default.
- W1978534013 hasAuthorship W1978534013A5057748104 @default.
- W1978534013 hasAuthorship W1978534013A5084251667 @default.
- W1978534013 hasConcept C126322002 @default.
- W1978534013 hasConcept C134018914 @default.
- W1978534013 hasConcept C185592680 @default.
- W1978534013 hasConcept C2777391703 @default.
- W1978534013 hasConcept C2777927741 @default.
- W1978534013 hasConcept C2779306644 @default.
- W1978534013 hasConcept C28859421 @default.
- W1978534013 hasConcept C3018667095 @default.
- W1978534013 hasConcept C55493867 @default.
- W1978534013 hasConcept C71924100 @default.
- W1978534013 hasConcept C86803240 @default.
- W1978534013 hasConceptScore W1978534013C126322002 @default.
- W1978534013 hasConceptScore W1978534013C134018914 @default.
- W1978534013 hasConceptScore W1978534013C185592680 @default.
- W1978534013 hasConceptScore W1978534013C2777391703 @default.
- W1978534013 hasConceptScore W1978534013C2777927741 @default.
- W1978534013 hasConceptScore W1978534013C2779306644 @default.
- W1978534013 hasConceptScore W1978534013C28859421 @default.
- W1978534013 hasConceptScore W1978534013C3018667095 @default.
- W1978534013 hasConceptScore W1978534013C55493867 @default.
- W1978534013 hasConceptScore W1978534013C71924100 @default.
- W1978534013 hasConceptScore W1978534013C86803240 @default.
- W1978534013 hasIssue "12" @default.
- W1978534013 hasLocation W19785340131 @default.
- W1978534013 hasLocation W19785340132 @default.
- W1978534013 hasOpenAccess W1978534013 @default.
- W1978534013 hasPrimaryLocation W19785340131 @default.
- W1978534013 hasRelatedWork W138803513 @default.
- W1978534013 hasRelatedWork W1974106130 @default.
- W1978534013 hasRelatedWork W1986132654 @default.
- W1978534013 hasRelatedWork W1997794058 @default.
- W1978534013 hasRelatedWork W2010140898 @default.