FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978535548> ?p ?o ?g. }

• W1978535548 endingPage "449" @default.
• W1978535548 startingPage "441" @default.
• W1978535548 abstract "There is some evidence that endothelins may be a signal mediator between neuronal and glial cells, at least in some regions of the brain. To evaluate this possibility, the localization of messenger RNAs for endothelin-converting enzymes and endothelin receptor B in the rat brain were examined using in situ hybridization histochemistry. The messenger RNAs for endothelin-converting enzyme-1 and endothelin-converting enzyme-2 were expressed mainly in neurons located in various brain regions, whereas the messenger RNA for endothelin receptor B was mainly localized in the astrocytes located throughout the brainstem, Bergmann glia, choroid plexus and ependymal cells. The localization patterns of endothelin-converting enzyme and endothelin receptor B messenger RNAs were strikingly different. For instance, in the cerebellum, endothelin-converting enzyme-1 messenger RNA was localized in Purkinje cells, and endothelin-converting enzyme-2 mRNA was expressed in Purkinje cells and granule cells. On the other hand, endothelin receptor B messenger RNA was expressed in Bergmann glia and the astrocytes located in the granule cell layer. This suggests that final cleavages of big endothelins are performed on neuronal cells, and the major target of the processed endothelins could be astrocytes, which express endothelin receptor B most abundantly in the brain. Since evidence that endothelin is implicated in brain injury has also accumulated, we examined whether the expressions of endothelin-converting enzymes and endothelin receptor B are regulated by nerve injury. Following hypoglossal nerve injury, expression of messenger RNA for endothelin-converting enzymes-1 and -2 and endothelin receptor B was enhanced in the injured motor neurons and astrocytes respectively. The up-regulation of these messenger RNAs was also confirmed by a reverse transcription-polymerase chain reaction based strategyThese results lead us to suggest that endothelin can be an inducible intercellular mediator between injured neurons and astrocytes in response to nerve injury." @default.
• W1978535548 created "2016-06-24" @default.
• W1978535548 creator A5067861929 @default.
• W1978535548 creator A5068238908 @default.
• W1978535548 creator A5075627852 @default.
• W1978535548 date "2000-11-01" @default.
• W1978535548 modified "2023-10-18" @default.
• W1978535548 title "Endothelin-converting enzymes and endothelin receptor B messenger RNAs are expressed in different neural cell species and these messenger RNAs are coordinately induced in neurons and astrocytes respectively following nerve injury" @default.
• W1978535548 cites W1538944936 @default.
• W1978535548 cites W1629134182 @default.
• W1978535548 cites W1951867641 @default.
• W1978535548 cites W1962496016 @default.
• W1978535548 cites W1965190482 @default.
• W1978535548 cites W1966959430 @default.
• W1978535548 cites W1971191442 @default.
• W1978535548 cites W1976046184 @default.
• W1978535548 cites W1976142920 @default.
• W1978535548 cites W1980762198 @default.
• W1978535548 cites W1983650913 @default.
• W1978535548 cites W1984621868 @default.
• W1978535548 cites W1999066497 @default.
• W1978535548 cites W1999088289 @default.
• W1978535548 cites W2002600185 @default.
• W1978535548 cites W2003470531 @default.
• W1978535548 cites W2004151231 @default.
• W1978535548 cites W2008580181 @default.
• W1978535548 cites W2017054020 @default.
• W1978535548 cites W2031203771 @default.
• W1978535548 cites W2039294026 @default.
• W1978535548 cites W2054473433 @default.
• W1978535548 cites W2061148571 @default.
• W1978535548 cites W2064488060 @default.
• W1978535548 cites W2066075836 @default.
• W1978535548 cites W2073485841 @default.
• W1978535548 cites W2081071769 @default.
• W1978535548 cites W2091948332 @default.
• W1978535548 cites W2094501268 @default.
• W1978535548 cites W2115789624 @default.
• W1978535548 cites W2151257004 @default.
• W1978535548 cites W2162804111 @default.
• W1978535548 doi "https://doi.org/10.1016/s0306-4522(00)00345-6" @default.
• W1978535548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11074166" @default.
• W1978535548 hasPublicationYear "2000" @default.
• W1978535548 type Work @default.
• W1978535548 sameAs 1978535548 @default.
• W1978535548 citedByCount "67" @default.
• W1978535548 countsByYear W19785355482012 @default.
• W1978535548 countsByYear W19785355482013 @default.
• W1978535548 countsByYear W19785355482014 @default.
• W1978535548 countsByYear W19785355482015 @default.
• W1978535548 countsByYear W19785355482016 @default.
• W1978535548 countsByYear W19785355482017 @default.
• W1978535548 countsByYear W19785355482018 @default.
• W1978535548 countsByYear W19785355482019 @default.
• W1978535548 countsByYear W19785355482021 @default.
• W1978535548 countsByYear W19785355482023 @default.
• W1978535548 crossrefType "journal-article" @default.
• W1978535548 hasAuthorship W1978535548A5067861929 @default.
• W1978535548 hasAuthorship W1978535548A5068238908 @default.
• W1978535548 hasAuthorship W1978535548A5075627852 @default.
• W1978535548 hasConcept C104317684 @default.
• W1978535548 hasConcept C105580179 @default.
• W1978535548 hasConcept C126322002 @default.
• W1978535548 hasConcept C134018914 @default.
• W1978535548 hasConcept C144980905 @default.
• W1978535548 hasConcept C163235415 @default.
• W1978535548 hasConcept C170493617 @default.
• W1978535548 hasConcept C2777542381 @default.
• W1978535548 hasConcept C2909649922 @default.
• W1978535548 hasConcept C2911175447 @default.
• W1978535548 hasConcept C529278444 @default.
• W1978535548 hasConcept C55493867 @default.
• W1978535548 hasConcept C71924100 @default.
• W1978535548 hasConcept C81439078 @default.
• W1978535548 hasConcept C86803240 @default.
• W1978535548 hasConcept C95444343 @default.
• W1978535548 hasConceptScore W1978535548C104317684 @default.
• W1978535548 hasConceptScore W1978535548C105580179 @default.
• W1978535548 hasConceptScore W1978535548C126322002 @default.
• W1978535548 hasConceptScore W1978535548C134018914 @default.
• W1978535548 hasConceptScore W1978535548C144980905 @default.
• W1978535548 hasConceptScore W1978535548C163235415 @default.
• W1978535548 hasConceptScore W1978535548C170493617 @default.
• W1978535548 hasConceptScore W1978535548C2777542381 @default.
• W1978535548 hasConceptScore W1978535548C2909649922 @default.
• W1978535548 hasConceptScore W1978535548C2911175447 @default.
• W1978535548 hasConceptScore W1978535548C529278444 @default.
• W1978535548 hasConceptScore W1978535548C55493867 @default.
• W1978535548 hasConceptScore W1978535548C71924100 @default.
• W1978535548 hasConceptScore W1978535548C81439078 @default.
• W1978535548 hasConceptScore W1978535548C86803240 @default.
• W1978535548 hasConceptScore W1978535548C95444343 @default.
• W1978535548 hasFunder F4320320912 @default.
• W1978535548 hasFunder F4320322034 @default.
• W1978535548 hasFunder F4320334764 @default.
• W1978535548 hasIssue "2" @default.
• W1978535548 hasLocation W19785355481 @default.
• W1978535548 hasLocation W19785355482 @default.

• next