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• W1978537102 abstract "OBJECTIVE To assess mitochondrial metabolism of bladder tissue induced by small‐intestinal submucosa (SIS), by comparing the mitochondrial enzyme metabolism in this tissue with that in normal bladder tissue and thus evaluate intracellular normality. MATERIAL AND METHODS In all, 70 rats were grouped into healthy controls (10), surgical controls with a simple bladder incision (15) and rats treated by partial cystectomy with replacement by the SIS graft (45). At 1, 3 and 6 months the rats were killed, the enzymes of mitochondrial respiratory chain complexes assayed, and the respiration of permeabilized bladder fibres assessed using polarographic analysis. RESULTS The enzyme activities of control and treated rats at 3 months were identical. The results from the polarographic analysis of respiration were also similar to that in normal tissue apart from a decrease in the number of mitochondria. Histologically, there was complete regeneration at 6 months. CONCLUSION After a phase of inflammation the bladder regenerates after a patch is placed. The new tissue has the same enzymatic and histological features as normal bladder tissue." @default.
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• W1978537102 date "2004-08-01" @default.
• W1978537102 modified "2023-10-16" @default.
• W1978537102 title "Mitochondrial metabolism in the rat during bladder regeneration induced by small intestinal submucosa" @default.
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• W1978537102 doi "https://doi.org/10.1111/j.1464-410x.2004.04845.x" @default.
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