FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978537223> ?p ?o ?g. }

• W1978537223 endingPage "11" @default.
• W1978537223 startingPage "6" @default.
• W1978537223 abstract "The aim of this study was to characterize the effects of sphingosine-1-phosphate (S1P) on cardiac ventricular fibroblasts. Impacts of S1P on fibroblast excitability, cell migration, proliferation and secretion were characterized. The patch-clamp technique in the whole-cell configuration was used to study the S1P-induced current from mouse ventricular fibroblasts. The expression level of the S1P receptor during cell culture duration was evaluated by western-blot. Fibroblast proliferation and migration were quantified using the methylene blue assay and the Boyden chamber technique, respectively. Finally, fibroblast secretion properties were estimated by quantification of the IL-6 and collagen levels using ELISA and SIRCOL collagen assays, respectively. We found that S1P activated SUR2/Kir6.1 channel and that this effect was sensitive to specific inhibition of the S1P receptor of type 3 (S1P3R). In contrast, S1P1R receptor inhibition had no effect. Moreover, the S1P-induced current increased with cell culture duration whereas S1P3R expression level remained constant. The activation of SUR2/Kir6.1 channel by S1P via S1P3R stimulated cell proliferation and decreased IL-6 and collagen secretions. S1P also stimulated fibroblast migration via S1P3R but independently from SUR2/Kir6.1 channel activation. This study demonstrates that S1P, via S1P3R, affects cardiac ventricular fibroblasts function independently or through activation of SUR2/Kir6.1 channel. The latter effect occurs after fibroblasts differentiate into myofibroblasts, opening a new potential therapeutic strategy to modulate fibrosis after cardiac physiopathological injury." @default.
• W1978537223 created "2016-06-24" @default.
• W1978537223 creator A5004894324 @default.
• W1978537223 creator A5025423853 @default.
• W1978537223 creator A5040834387 @default.
• W1978537223 creator A5051798906 @default.
• W1978537223 date "2011-04-01" @default.
• W1978537223 modified "2023-10-18" @default.
• W1978537223 title "Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts" @default.
• W1978537223 cites W1966452335 @default.
• W1978537223 cites W1968202984 @default.
• W1978537223 cites W1970977554 @default.
• W1978537223 cites W1997721028 @default.
• W1978537223 cites W2000508492 @default.
• W1978537223 cites W2006296665 @default.
• W1978537223 cites W2037787296 @default.
• W1978537223 cites W2042023519 @default.
• W1978537223 cites W2061457959 @default.
• W1978537223 cites W2083751915 @default.
• W1978537223 cites W2087495354 @default.
• W1978537223 cites W2095716238 @default.
• W1978537223 cites W2103341573 @default.
• W1978537223 cites W2118861337 @default.
• W1978537223 cites W2126411666 @default.
• W1978537223 cites W2129328611 @default.
• W1978537223 cites W2138345409 @default.
• W1978537223 cites W2144885443 @default.
• W1978537223 cites W2169291962 @default.
• W1978537223 cites W2169297355 @default.
• W1978537223 cites W2170350209 @default.
• W1978537223 doi "https://doi.org/10.1016/j.bbrc.2011.03.072" @default.
• W1978537223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21420933" @default.
• W1978537223 hasPublicationYear "2011" @default.
• W1978537223 type Work @default.
• W1978537223 sameAs 1978537223 @default.
• W1978537223 citedByCount "22" @default.
• W1978537223 countsByYear W19785372232012 @default.
• W1978537223 countsByYear W19785372232013 @default.
• W1978537223 countsByYear W19785372232014 @default.
• W1978537223 countsByYear W19785372232015 @default.
• W1978537223 countsByYear W19785372232016 @default.
• W1978537223 countsByYear W19785372232018 @default.
• W1978537223 countsByYear W19785372232019 @default.
• W1978537223 countsByYear W19785372232021 @default.
• W1978537223 countsByYear W19785372232023 @default.
• W1978537223 crossrefType "journal-article" @default.
• W1978537223 hasAuthorship W1978537223A5004894324 @default.
• W1978537223 hasAuthorship W1978537223A5025423853 @default.
• W1978537223 hasAuthorship W1978537223A5040834387 @default.
• W1978537223 hasAuthorship W1978537223A5051798906 @default.
• W1978537223 hasConcept C104317684 @default.
• W1978537223 hasConcept C126322002 @default.
• W1978537223 hasConcept C134018914 @default.
• W1978537223 hasConcept C147944092 @default.
• W1978537223 hasConcept C170493617 @default.
• W1978537223 hasConcept C185592680 @default.
• W1978537223 hasConcept C207865475 @default.
• W1978537223 hasConcept C2776415932 @default.
• W1978537223 hasConcept C2776596873 @default.
• W1978537223 hasConcept C2778703144 @default.
• W1978537223 hasConcept C2780381497 @default.
• W1978537223 hasConcept C2780559512 @default.
• W1978537223 hasConcept C54355233 @default.
• W1978537223 hasConcept C55493867 @default.
• W1978537223 hasConcept C62112901 @default.
• W1978537223 hasConcept C71924100 @default.
• W1978537223 hasConcept C81885089 @default.
• W1978537223 hasConcept C86803240 @default.
• W1978537223 hasConcept C95444343 @default.
• W1978537223 hasConceptScore W1978537223C104317684 @default.
• W1978537223 hasConceptScore W1978537223C126322002 @default.
• W1978537223 hasConceptScore W1978537223C134018914 @default.
• W1978537223 hasConceptScore W1978537223C147944092 @default.
• W1978537223 hasConceptScore W1978537223C170493617 @default.
• W1978537223 hasConceptScore W1978537223C185592680 @default.
• W1978537223 hasConceptScore W1978537223C207865475 @default.
• W1978537223 hasConceptScore W1978537223C2776415932 @default.
• W1978537223 hasConceptScore W1978537223C2776596873 @default.
• W1978537223 hasConceptScore W1978537223C2778703144 @default.
• W1978537223 hasConceptScore W1978537223C2780381497 @default.
• W1978537223 hasConceptScore W1978537223C2780559512 @default.
• W1978537223 hasConceptScore W1978537223C54355233 @default.
• W1978537223 hasConceptScore W1978537223C55493867 @default.
• W1978537223 hasConceptScore W1978537223C62112901 @default.
• W1978537223 hasConceptScore W1978537223C71924100 @default.
• W1978537223 hasConceptScore W1978537223C81885089 @default.
• W1978537223 hasConceptScore W1978537223C86803240 @default.
• W1978537223 hasConceptScore W1978537223C95444343 @default.
• W1978537223 hasIssue "1" @default.
• W1978537223 hasLocation W19785372231 @default.
• W1978537223 hasLocation W19785372232 @default.
• W1978537223 hasLocation W19785372233 @default.
• W1978537223 hasOpenAccess W1978537223 @default.
• W1978537223 hasPrimaryLocation W19785372231 @default.
• W1978537223 hasRelatedWork W1577588025 @default.
• W1978537223 hasRelatedWork W1996846474 @default.
• W1978537223 hasRelatedWork W2018368842 @default.
• W1978537223 hasRelatedWork W2033472167 @default.

• next