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• W1978537489 abstract "Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia (AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic enhancer (G2DHE or -77-kb enhancer) is brought into close proximity to the EVI1 gene in inv(3)(q21;q26) inversions, leading to leukemogenesis. We examined the contribution of G2DHE to leukemogenesis by creating a bacterial artificial chromosome (BAC) transgenic model that recapitulates the inv(3)(q21;q26) allele. Transgenic mice harboring a linked BAC developed leukemia accompanied by EVI1 overexpression-neoplasia that was not detected in mice bearing the same transgene but that was missing the GATA2 enhancer. These results establish the mechanistic basis underlying the pathogenesis of a severe form of leukemia through aberrant expression of the EVI1 proto-oncogene." @default.
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• W1978537489 date "2014-04-01" @default.
• W1978537489 modified "2023-10-16" @default.
• W1978537489 title "A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21;q26) by Activating EVI1 Expression" @default.
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• W1978537489 doi "https://doi.org/10.1016/j.ccr.2014.02.008" @default.
• W1978537489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4012341" @default.
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