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- W1978537560 abstract "IL-22 is expressed by activated lymphocytes and is important in modulation of tissue responses during inflammation. The cytokine induces proliferative and antiapoptotic pathways in epithelial cells allowing enhanced cell survival. This can have positive effects, such as in the maintenance of epithelial barriers in the gastrointestinal tract, but also negative effects, such as contributing to colorectal tumorigenesis. Because IL-22 can be dual-natured, we hypothesized that its biological activity should be tightly regulated to limit IL-22 expression to the sites of inflammation. One such environmental cue could be low oxygen, which often accompanies inflammation. We show that in CD4 T cells IL-22 expression is upregulated in hypoxia. The <i>Il22</i> promoter contains a putative conserved hypoxic response element suggesting that the transcription factor HIF-1α may influence IL-22 expression. Differentiation in the presence of dimethyloxallyl glycine, a stabilizer of HIF-1α at normoxia, increased IL-22 expression. Using HIF-1α–deficient CD4 T cells, we show that hypoxic IL-22 upregulation is dependent on HIF-1α. These findings have implications on the regulation of <i>Il22</i> gene expression and the presence of the cytokine in different inflammatory environments." @default.
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- W1978537560 date "1999-01-09" @default.
- W1978537560 modified "2023-10-14" @default.
- W1978537560 title "ABC of sexual health: Female sexual problems II: sexual pain and sexual fears" @default.
- W1978537560 doi "https://doi.org/10.1136/bmj.318.7176.110" @default.
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