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• W1978539907 abstract "Abstract— Incubation of [2-3H]glycerol-labeled phosphatidylinositol with a crude cytosol fraction of rat brain in the presence of EDTA yielded [3H]lysophosphatidylinositol predominantly without accumulation of labeled monoacylglycerol and diacylglycerol. The pH optimum of this Phospholipase A activity was 8.0. The activity for phosphatidylinositol was twofold higher than for phosphatidylethanolamine, whereas phosphatidylcholine, phosphatidylserine, and phosphatidic acid were not hydrolyzed significantly under the conditions used. The phospholipase A activity for phosphatidylethanolamine was resolved in part from that for phosphatidylinositol by ammonium sulfate fractionation of the cytosol, indicating the existence of at least two forms of EDTA-insensitive phospholipase A. The positional specificity of the phosphatidylinositol-hydrolyzing activity was found to be that of a phospholipase A1, as radioactive lysophosphatidylinositol was produced from 1 -stearoyl-2-[1-14C]arachidonyl-sn-glycero-3-phosphoinositol without release of free arachidonate. A phospholipase C activity specific for lysophosphoinositides was found in a membrane fraction from rat brain, which was similar to that characterized in porcine platelets. The phospholipase C was demonstrated to hydrolyze the 2-acyl isomer as well as the 1-acyl isomer of lysophosphatidylinositol. Taken together, our results suggest a possible pathway through which phosphatidylinositol is selectively degraded to the 2-acyl isomer of lysophosphatidylinositol in a Ca2+-independeht manner, and subsequently converted to 2-monoacylglycerol in rat brain." @default.
• W1978539907 created "2016-06-24" @default.
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• W1978539907 date "1993-11-01" @default.
• W1978539907 modified "2023-10-17" @default.
• W1978539907 title "A Possible Pathway of Phosphoinositide Metabolism Through EDTA-Insensitive Phospholipase A₁Followed by Lysophosphoinositide-Specific Phospholipase C in Rat Brain" @default.
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• W1978539907 doi "https://doi.org/10.1111/j.1471-4159.1993.tb09829.x" @default.
• W1978539907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8229000" @default.
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