Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978541724> ?p ?o ?g. }
- W1978541724 endingPage "159" @default.
- W1978541724 startingPage "151" @default.
- W1978541724 abstract "Pyruvate is an important metabolic intermediate, and also is an effective scavenger of hydrogen peroxide and other reactive oxygen species (ROS). Pharmacological administration of pyruvate has been shown to improve organ function in animal models of oxidant-mediated cellular injury. However, pyruvate is relatively unstable in aqueous solutions, which could limit the therapeutic potential of this compound. Ethyl pyruvate (EP), a simple derivative of pyruvic acid, is also an ROS scavenger, but seems to exert pharmacological effects, such as suppression of inflammation, which are at least quantitatively different and in some instances are qualitatively distinct from those exerted by pyruvate anion. Treatment with EP has been shown to improve survival and/or ameliorate organ dysfunction in a wide variety of pre-clinical models of acute illnesses, such as severe sepsis, acute pancreatitis and stroke. Using other animal models, some studies have demonstrated that more prolonged treatment with EP can ameliorate inflammatory bowel disease or slow the rate of growth of malignant tumors. In a clinical trial of patients undergoing cardiac surgery, treatment with EP was shown to be safe, but it failed to improve outcome. The true therapeutic potential of EP and related compounds remains to be elucidated. In this review, some of the biochemical mechanisms, which might be responsible for the pharmacological effects of EP, are discussed." @default.
- W1978541724 created "2016-06-24" @default.
- W1978541724 creator A5046054592 @default.
- W1978541724 creator A5052569785 @default.
- W1978541724 date "2010-07-01" @default.
- W1978541724 modified "2023-10-05" @default.
- W1978541724 title "The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds" @default.
- W1978541724 cites W1491223110 @default.
- W1978541724 cites W150567169 @default.
- W1978541724 cites W1612279088 @default.
- W1978541724 cites W1693234450 @default.
- W1978541724 cites W1751530372 @default.
- W1978541724 cites W1933759996 @default.
- W1978541724 cites W1967201899 @default.
- W1978541724 cites W1969095734 @default.
- W1978541724 cites W1972632883 @default.
- W1978541724 cites W1973082103 @default.
- W1978541724 cites W1974137661 @default.
- W1978541724 cites W1974837260 @default.
- W1978541724 cites W1983379130 @default.
- W1978541724 cites W1985018109 @default.
- W1978541724 cites W1987135793 @default.
- W1978541724 cites W1989690549 @default.
- W1978541724 cites W1990618897 @default.
- W1978541724 cites W1995076465 @default.
- W1978541724 cites W1995600689 @default.
- W1978541724 cites W1998504249 @default.
- W1978541724 cites W1999102410 @default.
- W1978541724 cites W1999255870 @default.
- W1978541724 cites W1999329820 @default.
- W1978541724 cites W2003134078 @default.
- W1978541724 cites W2004266769 @default.
- W1978541724 cites W2007032123 @default.
- W1978541724 cites W2007539521 @default.
- W1978541724 cites W2008577129 @default.
- W1978541724 cites W2008854574 @default.
- W1978541724 cites W2009980769 @default.
- W1978541724 cites W2014732588 @default.
- W1978541724 cites W2021183201 @default.
- W1978541724 cites W2021588763 @default.
- W1978541724 cites W2022752402 @default.
- W1978541724 cites W2024735128 @default.
- W1978541724 cites W2024964682 @default.
- W1978541724 cites W2026754993 @default.
- W1978541724 cites W2032025454 @default.
- W1978541724 cites W2032050858 @default.
- W1978541724 cites W2033327522 @default.
- W1978541724 cites W2034232685 @default.
- W1978541724 cites W2038111403 @default.
- W1978541724 cites W2039953278 @default.
- W1978541724 cites W2041282671 @default.
- W1978541724 cites W2041522382 @default.
- W1978541724 cites W2042988570 @default.
- W1978541724 cites W2048754639 @default.
- W1978541724 cites W2063612208 @default.
- W1978541724 cites W2064143310 @default.
- W1978541724 cites W2065991399 @default.
- W1978541724 cites W2068001141 @default.
- W1978541724 cites W2069248968 @default.
- W1978541724 cites W2070063455 @default.
- W1978541724 cites W2074292061 @default.
- W1978541724 cites W2074495864 @default.
- W1978541724 cites W2076382201 @default.
- W1978541724 cites W2077523355 @default.
- W1978541724 cites W2078071611 @default.
- W1978541724 cites W2079565796 @default.
- W1978541724 cites W2080423276 @default.
- W1978541724 cites W2081243261 @default.
- W1978541724 cites W2084004727 @default.
- W1978541724 cites W2089104635 @default.
- W1978541724 cites W2094045196 @default.
- W1978541724 cites W2094863064 @default.
- W1978541724 cites W2098962649 @default.
- W1978541724 cites W2106038477 @default.
- W1978541724 cites W2117612341 @default.
- W1978541724 cites W2118061802 @default.
- W1978541724 cites W2118725687 @default.
- W1978541724 cites W2122386753 @default.
- W1978541724 cites W2123328403 @default.
- W1978541724 cites W2135004711 @default.
- W1978541724 cites W2135291742 @default.
- W1978541724 cites W2136005561 @default.
- W1978541724 cites W2139680138 @default.
- W1978541724 cites W2140609738 @default.
- W1978541724 cites W2142645197 @default.
- W1978541724 cites W2142802089 @default.
- W1978541724 cites W2145561867 @default.
- W1978541724 cites W2147993424 @default.
- W1978541724 cites W2148937254 @default.
- W1978541724 cites W2151178097 @default.
- W1978541724 cites W2155418488 @default.
- W1978541724 cites W2166781237 @default.
- W1978541724 cites W2169565682 @default.
- W1978541724 cites W2169860535 @default.
- W1978541724 cites W2395464533 @default.
- W1978541724 cites W29263772 @default.
- W1978541724 cites W4297846776 @default.
- W1978541724 cites W43473650 @default.