Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978543883> ?p ?o ?g. }
- W1978543883 endingPage "464" @default.
- W1978543883 startingPage "454" @default.
- W1978543883 abstract "Conjugated equine estrogen (CEE) is the most commonly prescribed estrogen therapy, and is the estrogen used in the Women's Health Initiative study. While in-vitro studies suggest that CEE is neuroprotective, no study has evaluated CEE's effects on a cognitive battery and brain immunohistochemistry in an animal model. The current experiment tested whether CEE impacted: I) spatial learning, reference memory, working memory and long-term retention, as well as ability to handle mnemonic delay and interference challenges; and, II) the cholinergic system, via pharmacological challenge during memory testing and ChAT-immunoreactive cell counts in the basal forebrain. Middle-aged ovariectomized (Ovx) rats received chronic cyclic injections of either Oil (vehicle), CEE-Low (10 μg), CEE-Medium (20 μg) or CEE-High (30 μg) treatment. Relative to the Oil group, all three CEE groups showed less overnight forgetting on the spatial reference memory task, and the CEE-High group had enhanced platform localization during the probe trial. All CEE groups exhibited enhanced learning on the spatial working memory task, and CEE dose-dependently protected against scopolamine-induced amnesia with every rat receiving the highest CEE dose maintaining zero errors after scopolamine challenge. CEE also increased number of ChAT-immunoreactive neurons in the vertical diagonal band of the basal forebrain. Neither the ability to remember after a delay nor interference, nor long-term retention, was influenced by the CEE regimen used in this study. These findings are similar to those reported previously for 17 β-estradiol, and suggest that CEE can provide cognitive benefits on spatial learning, reference and working memory, possibly through cholinergic mechanisms." @default.
- W1978543883 created "2016-06-24" @default.
- W1978543883 creator A5006414984 @default.
- W1978543883 creator A5006429014 @default.
- W1978543883 creator A5015978195 @default.
- W1978543883 creator A5021090481 @default.
- W1978543883 creator A5021210749 @default.
- W1978543883 creator A5024721220 @default.
- W1978543883 creator A5029664636 @default.
- W1978543883 creator A5046480469 @default.
- W1978543883 creator A5084153345 @default.
- W1978543883 date "2009-03-01" @default.
- W1978543883 modified "2023-10-16" @default.
- W1978543883 title "Premarin improves memory, prevents scopolamine-induced amnesia and increases number of basal forebrain choline acetyltransferase positive cells in middle-aged surgically menopausal rats" @default.
- W1978543883 cites W127265788 @default.
- W1978543883 cites W1484864026 @default.
- W1978543883 cites W1487246579 @default.
- W1978543883 cites W1529983368 @default.
- W1978543883 cites W1533670895 @default.
- W1978543883 cites W1675693161 @default.
- W1978543883 cites W1742433321 @default.
- W1978543883 cites W1808137900 @default.
- W1978543883 cites W1808478632 @default.
- W1978543883 cites W1966493435 @default.
- W1978543883 cites W1970761591 @default.
- W1978543883 cites W1971457115 @default.
- W1978543883 cites W1972471497 @default.
- W1978543883 cites W1973334224 @default.
- W1978543883 cites W1976426926 @default.
- W1978543883 cites W1976844363 @default.
- W1978543883 cites W1977121038 @default.
- W1978543883 cites W1977230392 @default.
- W1978543883 cites W1977598790 @default.
- W1978543883 cites W1977862283 @default.
- W1978543883 cites W1978061037 @default.
- W1978543883 cites W1982708468 @default.
- W1978543883 cites W1984333383 @default.
- W1978543883 cites W1985576401 @default.
- W1978543883 cites W1988391827 @default.
- W1978543883 cites W1988633109 @default.
- W1978543883 cites W1994513698 @default.
- W1978543883 cites W1996120399 @default.
- W1978543883 cites W2000374562 @default.
- W1978543883 cites W2002090514 @default.
- W1978543883 cites W2002297740 @default.
- W1978543883 cites W2004584009 @default.
- W1978543883 cites W2006107691 @default.
- W1978543883 cites W2006377495 @default.
- W1978543883 cites W2009059114 @default.
- W1978543883 cites W2011982125 @default.
- W1978543883 cites W2012776040 @default.
- W1978543883 cites W2014956063 @default.
- W1978543883 cites W2016978785 @default.
- W1978543883 cites W2017169966 @default.
- W1978543883 cites W2017809151 @default.
- W1978543883 cites W2023370527 @default.
- W1978543883 cites W2029817026 @default.
- W1978543883 cites W2032843033 @default.
- W1978543883 cites W2037122980 @default.
- W1978543883 cites W2041018937 @default.
- W1978543883 cites W2043652943 @default.
- W1978543883 cites W2045604089 @default.
- W1978543883 cites W2047218252 @default.
- W1978543883 cites W2049932034 @default.
- W1978543883 cites W2050716208 @default.
- W1978543883 cites W2054091180 @default.
- W1978543883 cites W2054223324 @default.
- W1978543883 cites W2054420201 @default.
- W1978543883 cites W2061310823 @default.
- W1978543883 cites W2062586571 @default.
- W1978543883 cites W2064200220 @default.
- W1978543883 cites W2066558048 @default.
- W1978543883 cites W2068972835 @default.
- W1978543883 cites W2068978877 @default.
- W1978543883 cites W2069700086 @default.
- W1978543883 cites W2071164190 @default.
- W1978543883 cites W2072716385 @default.
- W1978543883 cites W2073436852 @default.
- W1978543883 cites W2080344095 @default.
- W1978543883 cites W2080620114 @default.
- W1978543883 cites W2081217627 @default.
- W1978543883 cites W2084489557 @default.
- W1978543883 cites W2089089128 @default.
- W1978543883 cites W2092668202 @default.
- W1978543883 cites W2097563817 @default.
- W1978543883 cites W2102981966 @default.
- W1978543883 cites W2104231345 @default.
- W1978543883 cites W2117602683 @default.
- W1978543883 cites W2123652060 @default.
- W1978543883 cites W2131266318 @default.
- W1978543883 cites W2132024178 @default.
- W1978543883 cites W2132489993 @default.
- W1978543883 cites W2137007429 @default.
- W1978543883 cites W2141184400 @default.
- W1978543883 cites W2146523165 @default.
- W1978543883 cites W2146595381 @default.
- W1978543883 cites W2150633281 @default.
- W1978543883 cites W2153297147 @default.