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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978545629> ?p ?o ?g. }

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• W1978545629 abstract "3-Substituted (Z)-4-(4-N,N-dialkylaminophenylmethylene)-5(4H)-isoxazolones and related compounds were designed and prepared as candidates for structurally novel androgen antagonists. Several compounds showed potent anti-androgenic activity as assessed by nuclear androgen receptor binding assay and growth inhibition assay using androgen-dependent Shionogi carcinoma cells SC-3. They were approximately 10--220 times more potent than flutamide in these assay systems. They also showed anti-androgenic activity toward prostate tumor cell line LNCaP, which has an aberrant nuclear androgen receptor." @default.
• W1978545629 created "2016-06-24" @default.
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• W1978545629 date "2002-05-01" @default.
• W1978545629 modified "2023-10-18" @default.
• W1978545629 title "Novel Non-Steroidal/Non-Anilide Type Androgen Antagonists with an Isoxazolone Moiety" @default.
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• W1978545629 doi "https://doi.org/10.1016/s0968-0896(01)00421-7" @default.
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