FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978546687> ?p ?o ?g. }

• W1978546687 endingPage "76" @default.
• W1978546687 startingPage "64" @default.
• W1978546687 abstract "Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases behavioral activity. Enhanced cyclic nucleotide signaling is a well established route to producing changes in gene expression. We hypothesized that chronic suppression of PDE10A activity would have significant effects on gene expression in the striatum. A comparison of the expression profile of PDE10A knockout (KO) mice and wild-type mice after chronic PDE10A inhibition revealed altered expression of 19 overlapping genes with few significant changes outside the striatum or after administration of a PDE10A inhibitor to KO animals. Chronic inhibition of PDE10A produced up-regulation of mRNAs encoding genes that included prodynorphin, synaptotagmin10, phosphodiesterase 1C, glutamate decarboxylase 1, and diacylglycerol <i>O</i>-acyltransferase and a down-regulation of mRNAs encoding choline acetyltransferase and <i>Kv1.6</i>, suggesting long-term suppression of the PDE10A enzyme is consistent with altered striatal excitability and potential utility as a antipsychotic therapy. In addition, up-regulation of mRNAs encoding histone 3 (H3) and down-regulation of histone deacetylase 4, follistatin, and claspin mRNAs suggests activation of molecular cascades capable of neuroprotection. We used lentiviral delivery of cAMP response element (CRE)-luciferase reporter constructs into the striatum and live animal imaging of 2-{4-[-pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1<i>H</i>-pyrazol-3-yl]-phenoxymethyl}-quinoline succinic acid (TP-10)-induced luciferase activity to further demonstrate PDE10 inhibition results in CRE-mediated transcription. Consistent with potential neuroprotective cascades, we also demonstrate phosphorylation of mitogen- and stress-activated kinase 1 and H3 in vivo after TP-10 treatment. The observed changes in signaling and gene expression are predicted to provide neuroprotective effects in models of Huntington9s disease." @default.
• W1978546687 created "2016-06-24" @default.
• W1978546687 creator A5005338517 @default.
• W1978546687 creator A5033712952 @default.
• W1978546687 creator A5036382118 @default.
• W1978546687 creator A5040618221 @default.
• W1978546687 creator A5041662661 @default.
• W1978546687 creator A5061162850 @default.
• W1978546687 creator A5073850347 @default.
• W1978546687 creator A5076398741 @default.
• W1978546687 creator A5086759093 @default.
• W1978546687 creator A5087920551 @default.
• W1978546687 creator A5088755018 @default.
• W1978546687 date "2010-10-05" @default.
• W1978546687 modified "2023-09-26" @default.
• W1978546687 title "Chronic Suppression of Phosphodiesterase 10A Alters Striatal Expression of Genes Responsible for Neurotransmitter Synthesis, Neurotransmission, and Signaling Pathways Implicated in Huntington's Disease" @default.
• W1978546687 cites W1602960923 @default.
• W1978546687 cites W1965030220 @default.
• W1978546687 cites W1966745290 @default.
• W1978546687 cites W1969601547 @default.
• W1978546687 cites W1973377854 @default.
• W1978546687 cites W1974790023 @default.
• W1978546687 cites W1974971445 @default.
• W1978546687 cites W1975165097 @default.
• W1978546687 cites W1977383752 @default.
• W1978546687 cites W1982981376 @default.
• W1978546687 cites W1984481041 @default.
• W1978546687 cites W1987865156 @default.
• W1978546687 cites W1995130398 @default.
• W1978546687 cites W2004593375 @default.
• W1978546687 cites W2012291756 @default.
• W1978546687 cites W2012732096 @default.
• W1978546687 cites W2017279410 @default.
• W1978546687 cites W2018058179 @default.
• W1978546687 cites W2020818523 @default.
• W1978546687 cites W2021504413 @default.
• W1978546687 cites W2023405690 @default.
• W1978546687 cites W2035162334 @default.
• W1978546687 cites W2036212209 @default.
• W1978546687 cites W2054693278 @default.
• W1978546687 cites W2062483494 @default.
• W1978546687 cites W2073155897 @default.
• W1978546687 cites W2074067755 @default.
• W1978546687 cites W2075140941 @default.
• W1978546687 cites W2083624932 @default.
• W1978546687 cites W2101095954 @default.
• W1978546687 cites W2106726734 @default.
• W1978546687 cites W2115155255 @default.
• W1978546687 cites W2120718088 @default.
• W1978546687 cites W2130392097 @default.
• W1978546687 cites W2131162745 @default.
• W1978546687 cites W2135166711 @default.
• W1978546687 cites W2152553016 @default.
• W1978546687 cites W2324138891 @default.
• W1978546687 doi "https://doi.org/10.1124/jpet.110.173294" @default.
• W1978546687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20923867" @default.
• W1978546687 hasPublicationYear "2010" @default.
• W1978546687 type Work @default.
• W1978546687 sameAs 1978546687 @default.
• W1978546687 citedByCount "84" @default.
• W1978546687 countsByYear W19785466872012 @default.
• W1978546687 countsByYear W19785466872013 @default.
• W1978546687 countsByYear W19785466872014 @default.
• W1978546687 countsByYear W19785466872015 @default.
• W1978546687 countsByYear W19785466872016 @default.
• W1978546687 countsByYear W19785466872017 @default.
• W1978546687 countsByYear W19785466872018 @default.
• W1978546687 countsByYear W19785466872019 @default.
• W1978546687 countsByYear W19785466872020 @default.
• W1978546687 countsByYear W19785466872021 @default.
• W1978546687 countsByYear W19785466872022 @default.
• W1978546687 crossrefType "journal-article" @default.
• W1978546687 hasAuthorship W1978546687A5005338517 @default.
• W1978546687 hasAuthorship W1978546687A5033712952 @default.
• W1978546687 hasAuthorship W1978546687A5036382118 @default.
• W1978546687 hasAuthorship W1978546687A5040618221 @default.
• W1978546687 hasAuthorship W1978546687A5041662661 @default.
• W1978546687 hasAuthorship W1978546687A5061162850 @default.
• W1978546687 hasAuthorship W1978546687A5073850347 @default.
• W1978546687 hasAuthorship W1978546687A5076398741 @default.
• W1978546687 hasAuthorship W1978546687A5086759093 @default.
• W1978546687 hasAuthorship W1978546687A5087920551 @default.
• W1978546687 hasAuthorship W1978546687A5088755018 @default.
• W1978546687 hasConcept C126322002 @default.
• W1978546687 hasConcept C134018914 @default.
• W1978546687 hasConcept C170493617 @default.
• W1978546687 hasConcept C181199279 @default.
• W1978546687 hasConcept C185592680 @default.
• W1978546687 hasConcept C25498285 @default.
• W1978546687 hasConcept C2776668983 @default.
• W1978546687 hasConcept C2780062018 @default.
• W1978546687 hasConcept C513476851 @default.
• W1978546687 hasConcept C55493867 @default.
• W1978546687 hasConcept C62826618 @default.
• W1978546687 hasConcept C71924100 @default.
• W1978546687 hasConcept C79418042 @default.
• W1978546687 hasConcept C86803240 @default.
• W1978546687 hasConcept C95444343 @default.

• next