Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978546979> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1978546979 endingPage "670" @default.
- W1978546979 startingPage "663" @default.
- W1978546979 abstract "The cause of Paget's disease of bone (PDB) is unknown. In an attempt to ascertain the proportion of familial cases and evaluate the influence of genetic factors on the occurrence of the disease, a study was undertaken based on 35 PDB patients from our Unit. Their families were investigated, with the participation of a total of 128 first-degree relatives. Fourteen (40%) of these 35 index cases had at least one other first-degree relative affected with PDB and were defined as “familial.” The remaining 21 (60%) were considered “sporadic.” The frequency of males in the familial cases (79%) was significantly higher than among the sporadics (29%; p ≤ 0.01). Mean age at diagnosis (63.1 12.6 vs. 713 ± 8.7; p ≤ 0.02), proportion of polyostotic cases (85.7% vs. 52.4%, p ≤ 0.05), and mean number of involved bones per patient (436 ± 2.50 vs. 233 ± 1.93, p ≤ 0.01) differ significantly in the familial and sporadic groups. The disease appears to be transmitted via both paternal and maternal sides, and pedigree analysis suggested an autosomal dominant inheritance or multifactorial mechanism. Apart from green-and-blue eye color, which was clearly associated with familial grouping (OR 6.25, 95% CI 1.15–37.16, p ≤ 0.01), crude analysis on several genetically based traits and environmental variables revealed no other significant differences between the groups. The adjusted odds ratio estimated for green-and-blue eye color was 2.92 (95% CI 038–22.74). Although additional studies will be required to determine whether the high proportion of familial cases and the differences between these and the sporadic cases also exist in different geographic areas, our data support the existence of two distinct subtypes of PDB." @default.
- W1978546979 created "2016-06-24" @default.
- W1978546979 creator A5008181450 @default.
- W1978546979 creator A5012616319 @default.
- W1978546979 creator A5029083465 @default.
- W1978546979 creator A5035806059 @default.
- W1978546979 creator A5063584355 @default.
- W1978546979 date "2009-12-03" @default.
- W1978546979 modified "2023-10-10" @default.
- W1978546979 title "Frequency and characteristics of familial aggregation of paget's disease of bone" @default.
- W1978546979 cites W1965425372 @default.
- W1978546979 cites W1971907695 @default.
- W1978546979 cites W2011378997 @default.
- W1978546979 cites W2023556629 @default.
- W1978546979 cites W2032869036 @default.
- W1978546979 cites W2036757590 @default.
- W1978546979 cites W2040140453 @default.
- W1978546979 cites W2045132292 @default.
- W1978546979 cites W2068341194 @default.
- W1978546979 cites W2070247628 @default.
- W1978546979 cites W2074138272 @default.
- W1978546979 cites W2075042143 @default.
- W1978546979 cites W2111876273 @default.
- W1978546979 cites W2124413252 @default.
- W1978546979 cites W2128507151 @default.
- W1978546979 cites W2171881826 @default.
- W1978546979 cites W2341313852 @default.
- W1978546979 cites W4236985816 @default.
- W1978546979 cites W4367720748 @default.
- W1978546979 cites W2105299958 @default.
- W1978546979 doi "https://doi.org/10.1002/jbmr.5650100421" @default.
- W1978546979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7610939" @default.
- W1978546979 hasPublicationYear "2009" @default.
- W1978546979 type Work @default.
- W1978546979 sameAs 1978546979 @default.
- W1978546979 citedByCount "213" @default.
- W1978546979 countsByYear W19785469792012 @default.
- W1978546979 countsByYear W19785469792013 @default.
- W1978546979 countsByYear W19785469792014 @default.
- W1978546979 countsByYear W19785469792015 @default.
- W1978546979 countsByYear W19785469792016 @default.
- W1978546979 countsByYear W19785469792017 @default.
- W1978546979 countsByYear W19785469792018 @default.
- W1978546979 countsByYear W19785469792019 @default.
- W1978546979 countsByYear W19785469792020 @default.
- W1978546979 countsByYear W19785469792021 @default.
- W1978546979 countsByYear W19785469792022 @default.
- W1978546979 countsByYear W19785469792023 @default.
- W1978546979 crossrefType "journal-article" @default.
- W1978546979 hasAuthorship W1978546979A5008181450 @default.
- W1978546979 hasAuthorship W1978546979A5012616319 @default.
- W1978546979 hasAuthorship W1978546979A5029083465 @default.
- W1978546979 hasAuthorship W1978546979A5035806059 @default.
- W1978546979 hasAuthorship W1978546979A5063584355 @default.
- W1978546979 hasConcept C104317684 @default.
- W1978546979 hasConcept C126322002 @default.
- W1978546979 hasConcept C156957248 @default.
- W1978546979 hasConcept C203083617 @default.
- W1978546979 hasConcept C2776154862 @default.
- W1978546979 hasConcept C2776458010 @default.
- W1978546979 hasConcept C2779134260 @default.
- W1978546979 hasConcept C54355233 @default.
- W1978546979 hasConcept C71924100 @default.
- W1978546979 hasConcept C86803240 @default.
- W1978546979 hasConcept C90924648 @default.
- W1978546979 hasConceptScore W1978546979C104317684 @default.
- W1978546979 hasConceptScore W1978546979C126322002 @default.
- W1978546979 hasConceptScore W1978546979C156957248 @default.
- W1978546979 hasConceptScore W1978546979C203083617 @default.
- W1978546979 hasConceptScore W1978546979C2776154862 @default.
- W1978546979 hasConceptScore W1978546979C2776458010 @default.
- W1978546979 hasConceptScore W1978546979C2779134260 @default.
- W1978546979 hasConceptScore W1978546979C54355233 @default.
- W1978546979 hasConceptScore W1978546979C71924100 @default.
- W1978546979 hasConceptScore W1978546979C86803240 @default.
- W1978546979 hasConceptScore W1978546979C90924648 @default.
- W1978546979 hasIssue "4" @default.
- W1978546979 hasLocation W19785469791 @default.
- W1978546979 hasLocation W19785469792 @default.
- W1978546979 hasOpenAccess W1978546979 @default.
- W1978546979 hasPrimaryLocation W19785469791 @default.
- W1978546979 hasRelatedWork W1978546979 @default.
- W1978546979 hasRelatedWork W2005225634 @default.
- W1978546979 hasRelatedWork W2026541346 @default.
- W1978546979 hasRelatedWork W2063250755 @default.
- W1978546979 hasRelatedWork W2087654862 @default.
- W1978546979 hasRelatedWork W2120190485 @default.
- W1978546979 hasRelatedWork W2149335411 @default.
- W1978546979 hasRelatedWork W2535217928 @default.
- W1978546979 hasRelatedWork W2560219664 @default.
- W1978546979 hasRelatedWork W2798604652 @default.
- W1978546979 hasVolume "10" @default.
- W1978546979 isParatext "false" @default.
- W1978546979 isRetracted "false" @default.
- W1978546979 magId "1978546979" @default.
- W1978546979 workType "article" @default.