Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978547963> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W1978547963 abstract "Purpose - To determine whether neuroretinal function differs in healthy persons with and without common risk gene variants for age- related macular degeneration (AMD) and no ophthalmoscopic signs of AMD, and to compare those findings in persons with manifest early AMD. Methods and Participants - Neuroretinal function was assessed with the multifocal electroretinogram (mfERG) (VERIS, Redwood City, CA,) in 32 participants (22 healthy persons with no clinical signs of AMD and 10 early AMD patients). The 22 healthy participants with no AMD were risk genotypes for either the CFH (rs380390) and/or ARMS2 (rs10490920). We used a slow flash mfERG paradigm (3 inserted frames) and a 103 hexagon stimulus array. Recordings were made with DTL electrodes; fixation and eye movements were monitored online. Trough N1 to peak P1 (N1P1) response densities and P1-implicit times (IT) were analysed in 5 concentric rings. Results - N1P1 response densities (mean ± SD) for concentric rings 1-3 were on average significantly higher in at-risk genotypes (ring 1: 17.97 nV/deg2 ± 1.9, ring 2: 11.7 nV/deg2 ±1.3, ring 3: 8.7 nV/deg2 ± 0.7) compared to those without risk (ring 1: 13.7 nV/deg2 ± 1.9, ring 2: 9.2 nV/deg2 ±0.8, ring 3: 7.3 nV/deg2 ± 1.1) and compared to persons with early AMD (ring 1: 15.3 nV/deg2 ± 4.8, ring 2: 9.1 nV/deg2 ±2.3, ring 3 nV/deg2: 7.3± 1.3) (p<0.5). The group implicit times, P1-ITs for ring 1 were on average delayed in the early AMD patients (36.4 ms ± 1.0) compared to healthy participants with (35.1 ms ± 1.1) or without risk genotypes (34.8 ms ±1.3), although these differences were not significant. Conclusion - Neuroretinal function in persons with normal fundi can be differentiated into subgroups based on their genetics. Increased neuroretinal activity in persons who carry AMD risk genotypes may be due to genetically determined subclinical inflammatory and/or histological changes in the retina. Assessment of neuroretinal function in healthy persons genetically susceptible to AMD may be a useful early biomarker before there is clinical manifestation of AMD." @default.
- W1978547963 created "2016-06-24" @default.
- W1978547963 creator A5004961440 @default.
- W1978547963 creator A5045795880 @default.
- W1978547963 creator A5047400292 @default.
- W1978547963 date "2012-01-01" @default.
- W1978547963 modified "2023-09-27" @default.
- W1978547963 title "The relationship between CFH and ARMS2 genotypes and neuroretinal function in persons without age-related macular degeneration" @default.
- W1978547963 hasPublicationYear "2012" @default.
- W1978547963 type Work @default.
- W1978547963 sameAs 1978547963 @default.
- W1978547963 citedByCount "0" @default.
- W1978547963 crossrefType "journal-article" @default.
- W1978547963 hasAuthorship W1978547963A5004961440 @default.
- W1978547963 hasAuthorship W1978547963A5045795880 @default.
- W1978547963 hasAuthorship W1978547963A5047400292 @default.
- W1978547963 hasConcept C104317684 @default.
- W1978547963 hasConcept C118487528 @default.
- W1978547963 hasConcept C135763542 @default.
- W1978547963 hasConcept C2776403814 @default.
- W1978547963 hasConcept C54355233 @default.
- W1978547963 hasConcept C71924100 @default.
- W1978547963 hasConcept C86803240 @default.
- W1978547963 hasConceptScore W1978547963C104317684 @default.
- W1978547963 hasConceptScore W1978547963C118487528 @default.
- W1978547963 hasConceptScore W1978547963C135763542 @default.
- W1978547963 hasConceptScore W1978547963C2776403814 @default.
- W1978547963 hasConceptScore W1978547963C54355233 @default.
- W1978547963 hasConceptScore W1978547963C71924100 @default.
- W1978547963 hasConceptScore W1978547963C86803240 @default.
- W1978547963 hasLocation W19785479631 @default.
- W1978547963 hasOpenAccess W1978547963 @default.
- W1978547963 hasPrimaryLocation W19785479631 @default.
- W1978547963 hasRelatedWork W1531428662 @default.
- W1978547963 hasRelatedWork W1853674701 @default.
- W1978547963 hasRelatedWork W1961778296 @default.
- W1978547963 hasRelatedWork W1964183131 @default.
- W1978547963 hasRelatedWork W1977108489 @default.
- W1978547963 hasRelatedWork W1982445260 @default.
- W1978547963 hasRelatedWork W2024349232 @default.
- W1978547963 hasRelatedWork W2033723566 @default.
- W1978547963 hasRelatedWork W2088877648 @default.
- W1978547963 hasRelatedWork W2126814330 @default.
- W1978547963 hasRelatedWork W2138437064 @default.
- W1978547963 hasRelatedWork W2146800041 @default.
- W1978547963 hasRelatedWork W2158220198 @default.
- W1978547963 hasRelatedWork W2354168686 @default.
- W1978547963 hasRelatedWork W2589103217 @default.
- W1978547963 hasRelatedWork W2613015963 @default.
- W1978547963 hasRelatedWork W2884838869 @default.
- W1978547963 hasRelatedWork W3012392536 @default.
- W1978547963 hasRelatedWork W850564675 @default.
- W1978547963 hasRelatedWork W91872680 @default.
- W1978547963 isParatext "false" @default.
- W1978547963 isRetracted "false" @default.
- W1978547963 magId "1978547963" @default.
- W1978547963 workType "article" @default.