FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978548614> ?p ?o ?g. }

• W1978548614 endingPage "211" @default.
• W1978548614 startingPage "211" @default.
• W1978548614 abstract "The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage Sameer Fatani1, Imose Itua2, Paul Clark3, Christopher Wong3, Ebrahim K Naderali21Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK; 2Department of Health and Applied Social Sciences, Liverpool Hope University, Hope Park, Liverpool UK; 3Aintree University Hospital NHS Foundation Trust, Longmoor Lane, Liverpool, UKAbstract: The prevalence of diet-induced obesity is increasing amongst adults and children worldwide, predisposing millions of people to an array of health problems that include metabolic syndrome, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. In this study we used experimental animals to investigate the effects of dietary obesity on markers of hepatic insulin signaling as well as structural changes in hepatocytes. Adult male Wistar rats were randomized and assigned to either a control group or a test group. Controls were fed standard laboratory pelleted diet (chow-fed), while the test group had free access to a highly-palatable diet (HPD). After eight weeks, the HPD-fed animals were subdivided into three subgroups and their diets altered as follows: HPD-to-chow, HPD with the addition of fenofibrate given by oral gavage for a further seven weeks, or HPD with vehicle (1% carboxymethylcellulose at 1 mL/kg body weight) given by oral gavage for a further seven weeks, respectively. Untreated diet-fed animals had significantly higher body weight, liver weight, and all measured metabolic profiles compared with chow-fed and treated diet-fed groups. Expression of kinases IRβ, IRS-1, AKt, eNOS, Shc and ERK1/2 were unaffected by obesity, while IRS-2 and P I3 kinase levels were significantly reduced in untreated HPD animals. Compared with chow-fed animals, steatosis and steatohepatitis were almost doubled in animals from untreated HPD, while removal of HPD and fenofibrate-treatment reduced steatosis by 40% and 80% respectively. These data suggest that diet-induced obesity affects intracellular insulin signaling mechanisms, namely IRS-2 and PI 3-kinase, leading to hepatic insulin resistance. Moreover, diet-induced obesity induces fatty liver, an effect which can be reversed by either removal of the source of obesity or treatment with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist.Keywords: obesity, non-alcoholic steatohepatitis, hepatocyte insulin signaling, fenofibrate" @default.
• W1978548614 created "2016-06-24" @default.
• W1978548614 creator A5003085119 @default.
• W1978548614 creator A5040266351 @default.
• W1978548614 creator A5041283393 @default.
• W1978548614 creator A5054280732 @default.
• W1978548614 creator A5077423554 @default.
• W1978548614 date "2011-03-01" @default.
• W1978548614 modified "2023-10-18" @default.
• W1978548614 title "The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage" @default.
• W1978548614 cites W146127655 @default.
• W1978548614 cites W1545747221 @default.
• W1978548614 cites W1651866740 @default.
• W1978548614 cites W1675830194 @default.
• W1978548614 cites W1780663168 @default.
• W1978548614 cites W1963533730 @default.
• W1978548614 cites W1983297041 @default.
• W1978548614 cites W1984513597 @default.
• W1978548614 cites W1989036548 @default.
• W1978548614 cites W2001901848 @default.
• W1978548614 cites W2013157141 @default.
• W1978548614 cites W2015643123 @default.
• W1978548614 cites W2016293185 @default.
• W1978548614 cites W2018803560 @default.
• W1978548614 cites W2019964639 @default.
• W1978548614 cites W2040735050 @default.
• W1978548614 cites W2041044388 @default.
• W1978548614 cites W2041398929 @default.
• W1978548614 cites W2047583916 @default.
• W1978548614 cites W2066113061 @default.
• W1978548614 cites W2066849422 @default.
• W1978548614 cites W2068494384 @default.
• W1978548614 cites W2069185580 @default.
• W1978548614 cites W2080353970 @default.
• W1978548614 cites W2087829753 @default.
• W1978548614 cites W2088366586 @default.
• W1978548614 cites W2088995677 @default.
• W1978548614 cites W2093880435 @default.
• W1978548614 cites W2097055679 @default.
• W1978548614 cites W2102434966 @default.
• W1978548614 cites W2118688616 @default.
• W1978548614 cites W2130001481 @default.
• W1978548614 cites W2130079031 @default.
• W1978548614 cites W2130742202 @default.
• W1978548614 cites W2146845495 @default.
• W1978548614 cites W2158979163 @default.
• W1978548614 cites W2160555596 @default.
• W1978548614 cites W2175315926 @default.
• W1978548614 cites W2333079875 @default.
• W1978548614 cites W2470937121 @default.
• W1978548614 cites W211618275 @default.
• W1978548614 doi "https://doi.org/10.2147/ijgm.s17376" @default.
• W1978548614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3068881" @default.
• W1978548614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21475632" @default.
• W1978548614 hasPublicationYear "2011" @default.
• W1978548614 type Work @default.
• W1978548614 sameAs 1978548614 @default.
• W1978548614 citedByCount "15" @default.
• W1978548614 countsByYear W19785486142012 @default.
• W1978548614 countsByYear W19785486142013 @default.
• W1978548614 countsByYear W19785486142014 @default.
• W1978548614 countsByYear W19785486142015 @default.
• W1978548614 countsByYear W19785486142016 @default.
• W1978548614 countsByYear W19785486142017 @default.
• W1978548614 countsByYear W19785486142018 @default.
• W1978548614 countsByYear W19785486142019 @default.
• W1978548614 countsByYear W19785486142022 @default.
• W1978548614 crossrefType "journal-article" @default.
• W1978548614 hasAuthorship W1978548614A5003085119 @default.
• W1978548614 hasAuthorship W1978548614A5040266351 @default.
• W1978548614 hasAuthorship W1978548614A5041283393 @default.
• W1978548614 hasAuthorship W1978548614A5054280732 @default.
• W1978548614 hasAuthorship W1978548614A5077423554 @default.
• W1978548614 hasBestOaLocation W19785486141 @default.
• W1978548614 hasConcept C126322002 @default.
• W1978548614 hasConcept C134018914 @default.
• W1978548614 hasConcept C202751555 @default.
• W1978548614 hasConcept C2776200302 @default.
• W1978548614 hasConcept C2778772119 @default.
• W1978548614 hasConcept C2779134260 @default.
• W1978548614 hasConcept C2779306644 @default.
• W1978548614 hasConcept C2779478299 @default.
• W1978548614 hasConcept C2780578515 @default.
• W1978548614 hasConcept C511355011 @default.
• W1978548614 hasConcept C55493867 @default.
• W1978548614 hasConcept C71924100 @default.
• W1978548614 hasConcept C86803240 @default.
• W1978548614 hasConceptScore W1978548614C126322002 @default.
• W1978548614 hasConceptScore W1978548614C134018914 @default.
• W1978548614 hasConceptScore W1978548614C202751555 @default.
• W1978548614 hasConceptScore W1978548614C2776200302 @default.
• W1978548614 hasConceptScore W1978548614C2778772119 @default.
• W1978548614 hasConceptScore W1978548614C2779134260 @default.
• W1978548614 hasConceptScore W1978548614C2779306644 @default.
• W1978548614 hasConceptScore W1978548614C2779478299 @default.
• W1978548614 hasConceptScore W1978548614C2780578515 @default.
• W1978548614 hasConceptScore W1978548614C511355011 @default.
• W1978548614 hasConceptScore W1978548614C55493867 @default.

• next