FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978548948> ?p ?o ?g. }

• W1978548948 endingPage "668" @default.
• W1978548948 startingPage "662" @default.
• W1978548948 abstract "Integrin α3β1 is expressed on many types of cancer cells and can regulate tumor growth and progression. In the present study, we examined the roles and molecular mechanism of integrin α3β1 in modulating cell proliferation and migration of p53-deficient non-small cell lung cancer (NSCLC) cells. Reduced expression of integrin α3 by RNA silencing clearly induces cell proliferation and migration in H1299 cells, compared with those in control cells. Enhanced proliferation in integrin α3-silenced cells is mediated by upregulation and nuclear localization of cyclin-dependent kinases, and these effects require the activation of Akt and ERK as evidenced by treatment with LY294002 and PD98059, respectively. Furthermore, suppression of integrin α3 expression induces the expression of nuclear factor-κB and Bcl-2 as well as epidermal growth factor receptor, which are positively correlated with cell proliferation and survival. In contrast, increase in cell migration of integrin α3-silenced cells is found to be independent of Akt or ERK signaling pathways. Collectively, these findings suggest that integrin α3β1 plays pivotal roles in regulating cell proliferation and migration that enhance the invasive type of p53-deficient NSCLC cells." @default.
• W1978548948 created "2016-06-24" @default.
• W1978548948 creator A5019489608 @default.
• W1978548948 creator A5044806903 @default.
• W1978548948 creator A5056996598 @default.
• W1978548948 creator A5084815079 @default.
• W1978548948 date "2012-12-06" @default.
• W1978548948 modified "2023-10-18" @default.
• W1978548948 title "Knockdown of integrin α3β1 expression induces proliferation and migration of non-small cell lung cancer cells" @default.
• W1978548948 cites W1576773659 @default.
• W1978548948 cites W1966022051 @default.
• W1978548948 cites W1967394241 @default.
• W1978548948 cites W1972071205 @default.
• W1978548948 cites W1974024530 @default.
• W1978548948 cites W1975097885 @default.
• W1978548948 cites W1999781470 @default.
• W1978548948 cites W2007725137 @default.
• W1978548948 cites W2010233812 @default.
• W1978548948 cites W2015723871 @default.
• W1978548948 cites W2015788325 @default.
• W1978548948 cites W2027329004 @default.
• W1978548948 cites W2028415754 @default.
• W1978548948 cites W2041400374 @default.
• W1978548948 cites W2042073539 @default.
• W1978548948 cites W2049939460 @default.
• W1978548948 cites W2050603039 @default.
• W1978548948 cites W2057624546 @default.
• W1978548948 cites W2060869819 @default.
• W1978548948 cites W2064241859 @default.
• W1978548948 cites W2065940152 @default.
• W1978548948 cites W2072259101 @default.
• W1978548948 cites W2072379478 @default.
• W1978548948 cites W2089813108 @default.
• W1978548948 cites W2108713158 @default.
• W1978548948 cites W2117692326 @default.
• W1978548948 cites W2118969537 @default.
• W1978548948 cites W2123759534 @default.
• W1978548948 cites W2147000598 @default.
• W1978548948 cites W2181524176 @default.
• W1978548948 cites W2223364205 @default.
• W1978548948 doi "https://doi.org/10.3892/or.2012.2169" @default.
• W1978548948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23233127" @default.
• W1978548948 hasPublicationYear "2012" @default.
• W1978548948 type Work @default.
• W1978548948 sameAs 1978548948 @default.
• W1978548948 citedByCount "19" @default.
• W1978548948 countsByYear W19785489482013 @default.
• W1978548948 countsByYear W19785489482014 @default.
• W1978548948 countsByYear W19785489482015 @default.
• W1978548948 countsByYear W19785489482016 @default.
• W1978548948 countsByYear W19785489482017 @default.
• W1978548948 countsByYear W19785489482020 @default.
• W1978548948 countsByYear W19785489482022 @default.
• W1978548948 crossrefType "journal-article" @default.
• W1978548948 hasAuthorship W1978548948A5019489608 @default.
• W1978548948 hasAuthorship W1978548948A5044806903 @default.
• W1978548948 hasAuthorship W1978548948A5056996598 @default.
• W1978548948 hasAuthorship W1978548948A5084815079 @default.
• W1978548948 hasBestOaLocation W19785489481 @default.
• W1978548948 hasConcept C104317684 @default.
• W1978548948 hasConcept C119056186 @default.
• W1978548948 hasConcept C137738243 @default.
• W1978548948 hasConcept C1491633281 @default.
• W1978548948 hasConcept C195687474 @default.
• W1978548948 hasConcept C22615655 @default.
• W1978548948 hasConcept C2781018059 @default.
• W1978548948 hasConcept C29537977 @default.
• W1978548948 hasConcept C502942594 @default.
• W1978548948 hasConcept C54009773 @default.
• W1978548948 hasConcept C54355233 @default.
• W1978548948 hasConcept C55493867 @default.
• W1978548948 hasConcept C57074206 @default.
• W1978548948 hasConcept C62112901 @default.
• W1978548948 hasConcept C62478195 @default.
• W1978548948 hasConcept C75217442 @default.
• W1978548948 hasConcept C81885089 @default.
• W1978548948 hasConcept C86554907 @default.
• W1978548948 hasConcept C86803240 @default.
• W1978548948 hasConcept C95444343 @default.
• W1978548948 hasConceptScore W1978548948C104317684 @default.
• W1978548948 hasConceptScore W1978548948C119056186 @default.
• W1978548948 hasConceptScore W1978548948C137738243 @default.
• W1978548948 hasConceptScore W1978548948C1491633281 @default.
• W1978548948 hasConceptScore W1978548948C195687474 @default.
• W1978548948 hasConceptScore W1978548948C22615655 @default.
• W1978548948 hasConceptScore W1978548948C2781018059 @default.
• W1978548948 hasConceptScore W1978548948C29537977 @default.
• W1978548948 hasConceptScore W1978548948C502942594 @default.
• W1978548948 hasConceptScore W1978548948C54009773 @default.
• W1978548948 hasConceptScore W1978548948C54355233 @default.
• W1978548948 hasConceptScore W1978548948C55493867 @default.
• W1978548948 hasConceptScore W1978548948C57074206 @default.
• W1978548948 hasConceptScore W1978548948C62112901 @default.
• W1978548948 hasConceptScore W1978548948C62478195 @default.
• W1978548948 hasConceptScore W1978548948C75217442 @default.
• W1978548948 hasConceptScore W1978548948C81885089 @default.
• W1978548948 hasConceptScore W1978548948C86554907 @default.
• W1978548948 hasConceptScore W1978548948C86803240 @default.

• next