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- W1978552125 abstract "OBJECTIVE: To determine whether prostaglandin E2 improves angiogenesis in full-thickness skin grafts. DESIGN: Randomized study SUBJECTS: 20 male rabbits, divided into 2 experimental and 2 control groups METHODOLOGY: Prostaglandin E2 (experimental groups) or prostaglandin E2 vehicle (control groups) was injected locally into experimental skin autografts once a day for up to 5 days. Five and 10 days after the surgery, the grafts were harvested and after processing, fractional and absolute volumes of the vessels were estimated in the grafted skin using stereologic methods. MAIN RESULTS: Gross appearance of the control and experimental grafts were the same. Qualitative histologic examination of successful grafts in experimental and control groups showed areas of viable epidermis with a negligible inflammatory infiltrate and moderate fibrosis. Blood cells were frequently seen in the vessels under investigation. Histologic slides showed significantly higher mean fractional volume (percent) and absolute volume of the vessels (mm3) per unit volume (mm3) of the grafted skin in the experimental groups than in the control groups. CONCLUSION: Fractional and absolute volume of the vessels were greater in prostaglandin E2-treated grafts than in the control grafts. Prostaglandin E2 appears to increase the volume of vessels in full-thickness skin grafts and can be explored as an agent to improve angiogenesis of the grafts." @default.
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- W1978552125 date "2004-05-01" @default.
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- W1978552125 title "Stereologic Study of the Effects of Prostaglandin E2 on the Induction of Angiogenesis in Full-Thickness Skin Autografts" @default.
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- W1978552125 doi "https://doi.org/10.1097/00129334-200405000-00020" @default.
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