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- W1978552468 abstract "Abstract In isolated hepatic mitochondria, sodium acetate had little effect on the oxidation of octanoate, but conspicuously inhibited the oxidation of palmitate. This differential effect of acetate on long-chain and short-chain fatty acid oxidation is not due to inhibition of the activation or transfer of long-chain fatty acids into the mitochondria. Both palmitate and octanoate reduced CO2 production from acetate. Palmitate and octanoate mutually inhibited CO2 production from each other to the same extent. Acetate stimulated ketogenesis from palmitoyl-1-carnitine to the same extent as it inhibited oxygen uptake and CO2 production from palmitate. This suggests that acetate causes a redistribution of the end products of palmitate oxidation toward ketogenesis rather than toward total oxidation to CO2 and H2O. Acetyl CoA derived from acetate or palmitate may share a common pool or pathway, thus each is mutally inhibitory toward the oxidation of the other. Either because of the existence of separate pools, or because octanoate is the preferred substrate, acetate metabolism does not inhibit O2 uptake or CO2 production from octanoate, whereas the oxidation of octanoate dilutes the CO2 produced from labeled acetate. This may be explained by compartmentation or preferred pathways for the disposition of acetyl CoA derived from different sources." @default.
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- W1978552468 date "1975-02-01" @default.
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- W1978552468 title "Differential effects of acetate on palmitate and octanoate oxidation: Segregation of acetyl CoA pools" @default.
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- W1978552468 doi "https://doi.org/10.1016/0003-9861(75)90428-2" @default.
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