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- W1978555736 abstract "Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops, dendritic cells from ileal Peyer's patches become infected and constitute a cell target for this pathogen. In vitro, we found that Brucella replicates within dendritic cells and hinders their functional activation. In addition, we identified a new Brucella protein Btp1, which down-modulates maturation of infected dendritic cells by interfering with the TLR2 signaling pathway. These results show that intracellular Brucella is able to control dendritic cell function, which may have important consequences in the development of chronic brucellosis." @default.
- W1978555736 created "2016-06-24" @default.
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- W1978555736 date "2008-02-08" @default.
- W1978555736 modified "2023-10-17" @default.
- W1978555736 title "Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1" @default.
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- W1978555736 doi "https://doi.org/10.1371/journal.ppat.0040021" @default.
- W1978555736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2233671" @default.
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- W1978555736 hasPublicationYear "2008" @default.
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