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- W1978558661 abstract "Inhaled chrysotile asbestos fibers impact upon epithelial cells which line the alveolar region of the lung. 1 Brody AR Hill LH Adkins B O’Connor RW Chrysotile asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages. Am Rev Respir Dis. 1981; 123: 670-679 PubMed Google Scholar Many of these fibers are taken up by alveolar epithelial cells. 1 Brody AR Hill LH Adkins B O’Connor RW Chrysotile asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages. Am Rev Respir Dis. 1981; 123: 670-679 PubMed Google Scholar During the 1-month period after a 1-hr exposure to chrysotile asbestos, numerous fibers are translocated to basement membranes as well as to interstitial cells and connective tissue. 1 Brody AR Hill LH Adkins B O’Connor RW Chrysotile asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages. Am Rev Respir Dis. 1981; 123: 670-679 PubMed Google Scholar , 2 Brody AR Hill LH Interstitial accumulation of inhaled chrysotile asbestos fibers and consequent formation of microcalcifications. Am J Pathol. 1982; 109: 107-114 PubMed Google Scholar The interstitial compartment at the alveolar level is the primary region affected during the pathogenesis of asbestosis. 3 Wagner JC Berry G Skidmore JW Timbrell V The effects of the inhalation of asbestos in rats. Br J Cancer. 1974; 29: 252-269 Crossref PubMed Scopus (403) Google Scholar We propose that actin-containing microfilaments of the alveolar epithelium provide a mechanism by which inhaled asbestos fibers are translocated to the pulmonary interstitium. The evidence to support this hypothesis has been achieved through ultrastructural studies of asbestosfilament associations in vivo and by quantitative biochemical studies of asbestos-epithelial interactions in vitro." @default.
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- W1978558661 date "1983-05-01" @default.
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- W1978558661 title "Actin-Containing Microfilaments of Pulmonary Epithelial Cells Provide a Mechanism for Translocating Asbestos to the Interstitium" @default.
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- W1978558661 doi "https://doi.org/10.1378/chest.83.5_supplement.11s" @default.
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