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- W1978558987 abstract "A 52-year-old male with an HIV infection (CD4 20 cells/mm and viral load copies/ml >1 million) who was not on antiretroviral therapy, presented with a 3-week history of skin lesions on the lower extremities, back, and chest (Figure 1). His skin lesions consisted of blisters as well as ulcers. One week after the skin lesions appeared he started to experience ataxia. Magnetic resonance imaging showed left periventricular white matter peripheral hemorrhagic lesions with precontrast T1 hyperintensity. PCR from one of his skin lesions and cerebrospinal fluid (CSF) were positive for varicella zoster virus (VZV). He was started on treatment with ganciclovir and there was a significant improvement in his symptoms. The incidence of herpes zoster in HIV patients has been reported to be 3.2–5.67 per 100 person-years. Highly active antiretroviral therapy has been associated with a decrease in herpes zoster, and low CD4 counts have been found to be the main risk factor. Invasion of the arteries by VZV can result in ischemia or hemorrhage in any vessel. Only 60% of patients have a rash prior to neurological symptoms. Positive VZV by PCR in CSF can be" @default.
- W1978558987 created "2016-06-24" @default.
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- W1978558987 date "2015-04-01" @default.
- W1978558987 modified "2023-09-27" @default.
- W1978558987 title "A man with skin lesions and ataxia: a case of disseminated varicella zoster" @default.
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- W1978558987 doi "https://doi.org/10.1016/j.ijid.2014.10.021" @default.
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