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• W1978559596 abstract "ObjectiveThe discovery of carbon monoxide (CO) and hydrogen sulfide (H2S) as pathogenic signaling molecules in airway-related diseases has led to significant insights into the pathophysiologic mechanisms underlying the development of allergic rhinitis (AR). The potential crosstalk between CO and H2S signaling pathways in AR has not been adequately investigated. This study was performed to elucidate the mechanistic relationship between CO and H2S in AR. Subjects and MethodsA well-established model of AR was used whereby guinea pigs (N = 24) were randomly divided into 4 treatment groups (n = 6 for each group): The first group received ovalbumin only; the second group was administered exogenous hemin, a CO-binding metalloporphyrin; the third group received zinc protoporphyrin, an inhibitor of heme oxygenase-1. A control group was challenged using only saline. Symptoms of AR were recorded, and quantitation of plasma CO and H2S levels was performed. Expression of heme oxygenase-1 and H2S-generating enzyme cystathionine-γ-lyase (CSE) were measured from nasal mucosa. ResultsPlasma CO and heme oxygenase-1 expression levels of nasal mucosa were significantly increased in the AR group compared to controls, whereas H2S concentrations were significantly decreased. Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression. Zinc protoporphyrin decreased CO concentrations and increased levels of both H2S and CSE expression. ConclusionsResults indicated an inverse relationship between H2S levels and CO in the pathogenesis of AR." @default.
• W1978559596 created "2016-06-24" @default.
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• W1978559596 date "2015-01-12" @default.
• W1978559596 modified "2023-10-16" @default.
• W1978559596 title "Impact of Carbon Monoxide/Heme Oxygenase on Hydrogen Sulfide/Cystathionine‐γ‐lyase Pathway in the Pathogenesis of Allergic Rhinitis in Guinea Pigs" @default.
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• W1978559596 doi "https://doi.org/10.1177/0194599814567112" @default.
• W1978559596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25583855" @default.
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