FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978562134> ?p ?o ?g. }

• W1978562134 endingPage "8848" @default.
• W1978562134 startingPage "8838" @default.
• W1978562134 abstract "ABSTRACT The hepatitis C virus (HCV) RNA replication complex (RC), which is composed of viral nonstructural (NS) proteins and host cellular proteins, replicates the viral RNA genome in association with intracellular membranes. Two viral NS proteins, NS3 and NS5A, are essential elements of the RC. Here, by using immunoprecipitation and fluorescence resonance energy transfer assays, we demonstrated that NS3 and NS5A interact with tubulin and actin. Furthermore, immunofluorescence microscopy and electron microscopy revealed that HCV RCs were aligned along microtubules and actin filaments in both HCV replicon cells and HCV-infected cells. In addition, the movement of RCs was inhibited when microtubules or actin filaments were depolymerized by colchicine and cytochalasin B, respectively. Based on our observations, we propose that microtubules and actin filaments provide the tracks for the movement of HCV RCs to other regions in the cell, and the molecular interactions between RCs and microtubules, or RCs and actin filaments, are mediated by NS3 and NS5A." @default.
• W1978562134 created "2016-06-24" @default.
• W1978562134 creator A5014034378 @default.
• W1978562134 creator A5029206852 @default.
• W1978562134 creator A5070288633 @default.
• W1978562134 creator A5088473072 @default.
• W1978562134 date "2008-09-01" @default.
• W1978562134 modified "2023-10-15" @default.
• W1978562134 title "Association of Hepatitis C Virus Replication Complexes with Microtubules and Actin Filaments Is Dependent on the Interaction of NS3 and NS5A" @default.
• W1978562134 cites W1638419681 @default.
• W1978562134 cites W1879138788 @default.
• W1978562134 cites W1963967855 @default.
• W1978562134 cites W1964468772 @default.
• W1978562134 cites W1964598018 @default.
• W1978562134 cites W1974865581 @default.
• W1978562134 cites W1987002413 @default.
• W1978562134 cites W1987984630 @default.
• W1978562134 cites W1988020128 @default.
• W1978562134 cites W1988237823 @default.
• W1978562134 cites W1996028735 @default.
• W1978562134 cites W2000544170 @default.
• W1978562134 cites W2003579943 @default.
• W1978562134 cites W2005280235 @default.
• W1978562134 cites W2009654376 @default.
• W1978562134 cites W2018659854 @default.
• W1978562134 cites W2021108691 @default.
• W1978562134 cites W2021199098 @default.
• W1978562134 cites W2023263503 @default.
• W1978562134 cites W2023273367 @default.
• W1978562134 cites W2023829232 @default.
• W1978562134 cites W2031110815 @default.
• W1978562134 cites W2036105845 @default.
• W1978562134 cites W2039025686 @default.
• W1978562134 cites W2049822037 @default.
• W1978562134 cites W2052213010 @default.
• W1978562134 cites W2054165784 @default.
• W1978562134 cites W2057967679 @default.
• W1978562134 cites W2069790213 @default.
• W1978562134 cites W2078887917 @default.
• W1978562134 cites W2081771560 @default.
• W1978562134 cites W2087963520 @default.
• W1978562134 cites W2089167315 @default.
• W1978562134 cites W2096820648 @default.
• W1978562134 cites W2100185018 @default.
• W1978562134 cites W2104356883 @default.
• W1978562134 cites W2105891409 @default.
• W1978562134 cites W2110671968 @default.
• W1978562134 cites W2115266867 @default.
• W1978562134 cites W2125159364 @default.
• W1978562134 cites W2126508001 @default.
• W1978562134 cites W2128427159 @default.
• W1978562134 cites W2132444008 @default.
• W1978562134 cites W2132879836 @default.
• W1978562134 cites W2136313958 @default.
• W1978562134 cites W2136523601 @default.
• W1978562134 cites W2150368001 @default.
• W1978562134 cites W2151394217 @default.
• W1978562134 cites W2151898297 @default.
• W1978562134 cites W2160425277 @default.
• W1978562134 cites W2166729753 @default.
• W1978562134 cites W2170402088 @default.
• W1978562134 cites W2790360897 @default.
• W1978562134 doi "https://doi.org/10.1128/jvi.00398-08" @default.
• W1978562134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2519648" @default.
• W1978562134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18562541" @default.
• W1978562134 hasPublicationYear "2008" @default.
• W1978562134 type Work @default.
• W1978562134 sameAs 1978562134 @default.
• W1978562134 citedByCount "87" @default.
• W1978562134 countsByYear W19785621342012 @default.
• W1978562134 countsByYear W19785621342013 @default.
• W1978562134 countsByYear W19785621342014 @default.
• W1978562134 countsByYear W19785621342015 @default.
• W1978562134 countsByYear W19785621342016 @default.
• W1978562134 countsByYear W19785621342017 @default.
• W1978562134 countsByYear W19785621342018 @default.
• W1978562134 countsByYear W19785621342019 @default.
• W1978562134 countsByYear W19785621342020 @default.
• W1978562134 countsByYear W19785621342021 @default.
• W1978562134 countsByYear W19785621342022 @default.
• W1978562134 countsByYear W19785621342023 @default.
• W1978562134 crossrefType "journal-article" @default.
• W1978562134 hasAuthorship W1978562134A5014034378 @default.
• W1978562134 hasAuthorship W1978562134A5029206852 @default.
• W1978562134 hasAuthorship W1978562134A5070288633 @default.
• W1978562134 hasAuthorship W1978562134A5088473072 @default.
• W1978562134 hasBestOaLocation W19785621341 @default.
• W1978562134 hasConcept C125705527 @default.
• W1978562134 hasConcept C132379496 @default.
• W1978562134 hasConcept C140704245 @default.
• W1978562134 hasConcept C142669718 @default.
• W1978562134 hasConcept C1491633281 @default.
• W1978562134 hasConcept C159047783 @default.
• W1978562134 hasConcept C20418707 @default.
• W1978562134 hasConcept C2522874641 @default.
• W1978562134 hasConcept C2776041460 @default.
• W1978562134 hasConcept C2776408679 @default.
• W1978562134 hasConcept C2777103181 @default.

• next