FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978569191> ?p ?o ?g. }

• W1978569191 endingPage "282" @default.
• W1978569191 startingPage "271" @default.
• W1978569191 abstract "The nucleus accumbens (NAc) is a site critical for the actions of many drugs of abuse. Psychoactive compounds, such as N-methyl-d-aspartate receptor (NMDAR) antagonists, modify gamma (40-90) and high frequency oscillations (HFO, 130–180 Hz) in local field potentials (LFPs) recorded in the NAc. Lysergic acid diethylamide (LSD) and 2,5-dimethoxy-4-iodoamphetamine (DOI) are serotonergic hallucinogens and activation of 5HT2A receptors likely underlies their hallucinogenic effects. Whether these compounds can also modulate LFP oscillations in the NAc is unclear. This study aims to examine the effect of serotonergic hallucinogens on gamma and HFO recorded in the NAc and to test whether 5HT2A receptors mediate the effects observed. LFPs were recorded from the NAc of freely moving rats. Drugs were administered intraperitoneally. LSD (0.03–0.3 mg/kg) and DOI (0.5–2.0 mg/kg) increased the power and reduced the frequency of HFO. In contrast, the hallucinogens produced a robust reduction in the power of low (40–60 Hz), but not high gamma oscillations (70–90 Hz). MDL 11939 (1.0 mg/kg), a 5HT2A receptor antagonist, fully reversed the changes induced by DOI on HFO but only partially for the low gamma band. Equivalent increases in HFO power were observed after TCB-2 (5HT2A receptor agonist, 0.1–1.5 mg/kg), but not CP 809101 (5H2C receptor agonist, 0.1–3 mg/kg). Notably, hallucinogen-induced increases in HFO power were smaller than those produced by ketamine (25 mg/kg). Serotonergic hallucinogen-induced changes in HFO and gamma are mediated, at least in part, by stimulation of 5HT2A receptors. Comparison of the oscillatory changes produced by serotonergic hallucinogens and NMDAR antagonists are also discussed." @default.
• W1978569191 created "2016-06-24" @default.
• W1978569191 creator A5011485672 @default.
• W1978569191 creator A5015418755 @default.
• W1978569191 creator A5020160223 @default.
• W1978569191 creator A5053618514 @default.
• W1978569191 creator A5065384564 @default.
• W1978569191 date "2013-03-23" @default.
• W1978569191 modified "2023-09-26" @default.
• W1978569191 title "Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens" @default.
• W1978569191 cites W164470940 @default.
• W1978569191 cites W1970689846 @default.
• W1978569191 cites W1981264895 @default.
• W1978569191 cites W1987154479 @default.
• W1978569191 cites W1995045083 @default.
• W1978569191 cites W1997935178 @default.
• W1978569191 cites W1998322518 @default.
• W1978569191 cites W2001522126 @default.
• W1978569191 cites W2009231298 @default.
• W1978569191 cites W2017011655 @default.
• W1978569191 cites W2017923649 @default.
• W1978569191 cites W2018145351 @default.
• W1978569191 cites W2019578492 @default.
• W1978569191 cites W2021435402 @default.
• W1978569191 cites W2026612602 @default.
• W1978569191 cites W2029012861 @default.
• W1978569191 cites W2033034887 @default.
• W1978569191 cites W2035632600 @default.
• W1978569191 cites W2047834876 @default.
• W1978569191 cites W2052238854 @default.
• W1978569191 cites W2053210895 @default.
• W1978569191 cites W2054989323 @default.
• W1978569191 cites W2054991032 @default.
• W1978569191 cites W2059689375 @default.
• W1978569191 cites W2062290393 @default.
• W1978569191 cites W2063177210 @default.
• W1978569191 cites W2068949066 @default.
• W1978569191 cites W2071655746 @default.
• W1978569191 cites W2073997074 @default.
• W1978569191 cites W2080123927 @default.
• W1978569191 cites W2093210784 @default.
• W1978569191 cites W2094608123 @default.
• W1978569191 cites W2104625331 @default.
• W1978569191 cites W2114192904 @default.
• W1978569191 cites W2117090183 @default.
• W1978569191 cites W2139358036 @default.
• W1978569191 cites W2140156016 @default.
• W1978569191 cites W2145095988 @default.
• W1978569191 cites W2147379823 @default.
• W1978569191 cites W2153770591 @default.
• W1978569191 cites W4211150788 @default.
• W1978569191 cites W4239438238 @default.
• W1978569191 cites W4245707768 @default.
• W1978569191 doi "https://doi.org/10.1007/s00213-013-3057-1" @default.
• W1978569191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3693439" @default.
• W1978569191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23525524" @default.
• W1978569191 hasPublicationYear "2013" @default.
• W1978569191 type Work @default.
• W1978569191 sameAs 1978569191 @default.
• W1978569191 citedByCount "32" @default.
• W1978569191 countsByYear W19785691912015 @default.
• W1978569191 countsByYear W19785691912016 @default.
• W1978569191 countsByYear W19785691912017 @default.
• W1978569191 countsByYear W19785691912018 @default.
• W1978569191 countsByYear W19785691912019 @default.
• W1978569191 countsByYear W19785691912020 @default.
• W1978569191 countsByYear W19785691912021 @default.
• W1978569191 countsByYear W19785691912022 @default.
• W1978569191 countsByYear W19785691912023 @default.
• W1978569191 crossrefType "journal-article" @default.
• W1978569191 hasAuthorship W1978569191A5011485672 @default.
• W1978569191 hasAuthorship W1978569191A5015418755 @default.
• W1978569191 hasAuthorship W1978569191A5020160223 @default.
• W1978569191 hasAuthorship W1978569191A5053618514 @default.
• W1978569191 hasAuthorship W1978569191A5065384564 @default.
• W1978569191 hasBestOaLocation W19785691911 @default.
• W1978569191 hasConcept C124315065 @default.
• W1978569191 hasConcept C126855140 @default.
• W1978569191 hasConcept C15744967 @default.
• W1978569191 hasConcept C169760540 @default.
• W1978569191 hasConcept C170493617 @default.
• W1978569191 hasConcept C185592680 @default.
• W1978569191 hasConcept C200220013 @default.
• W1978569191 hasConcept C2775864247 @default.
• W1978569191 hasConcept C2776552330 @default.
• W1978569191 hasConcept C2776885963 @default.
• W1978569191 hasConcept C2778938600 @default.
• W1978569191 hasConcept C2779871769 @default.
• W1978569191 hasConcept C37000724 @default.
• W1978569191 hasConcept C53910766 @default.
• W1978569191 hasConcept C55493867 @default.
• W1978569191 hasConcept C71924100 @default.
• W1978569191 hasConcept C98274493 @default.
• W1978569191 hasConceptScore W1978569191C124315065 @default.
• W1978569191 hasConceptScore W1978569191C126855140 @default.
• W1978569191 hasConceptScore W1978569191C15744967 @default.
• W1978569191 hasConceptScore W1978569191C169760540 @default.
• W1978569191 hasConceptScore W1978569191C170493617 @default.

• next