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• W1978570894 abstract "The c-Myc oncoprotein is strongly induced during the G0 to S-phase transition and is an important regulator of cell cycle entry. In contrast to c-Myc, the putative Myc antagonist Mnt is maintained at a constant level during cell cycle entry. Mnt and Myc require interaction with Max for specific DNA binding at E-box sites, but have opposing transcriptional activities. Here, we show that c-Myc induction during cell cycle entry leads to a transient decrease in Mnt–Max complexes and a transient switch in the ratio of Mnt–Max to c-Myc–Max on shared target genes. Mnt overexpression suppressed cell cycle entry and cell proliferation, suggesting that the ratio of Mnt–Max to c-Myc–Max is critical for cell cycle entry. Furthermore, simultaneous Cre-Lox mediated deletion of Mnt and c-Myc in mouse embryo fibroblasts rescued the cell cycle entry and proliferative block caused by c-Myc ablation alone. These results demonstrate that Mnt-Myc antagonism plays a fundamental role in regulating cell cycle entry and proliferation." @default.
• W1978570894 created "2016-06-24" @default.
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• W1978570894 date "2005-05-02" @default.
• W1978570894 modified "2023-10-03" @default.
• W1978570894 title "Mnt–Max to Myc–Max complex switching regulates cell cycle entry" @default.
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• W1978570894 doi "https://doi.org/10.1083/jcb.200411013" @default.
• W1978570894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2171929" @default.
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