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- W1978573089 abstract "Background 111In-pentetreotide scan (OctreoScan) is a widely available agent with high sensitivity for imaging neuroendocrine tumours. Negative 111In-pentetreotide poses diagnostic as well as therapeutic problems in terms of staging and consideration of targeted radionuclide therapy. Aim To assess the role of 99mTc-depreotide in patients with negative or weakly positive OctreoScan (Krenning score≤1; measured on a scale range 0–4). To determine the usefulness of 99mTc-depreotide scintigraphy for highlighting lesions that may be missed by OctreoScan and/or CT/MRI imaging. Study design Prospective analysis of 25 patients with neuroendocrine tumours, with negative or weakly positive 111In-pentetreotide scans, who were consecutively enrolled to undergo 111In-pentetreotide and 99mTc-depreotide imaging. The results were compared with either CT or MRI scans. Results Histology was available for 20 of 25 patients: of these 40% had high-grade tumours (cellular proliferation marker Ki-67 score >20%), a further 35% had intermediate-grade tumours (Ki-67 2–20%), and the remaining 25% had low-grade tumours (Ki-67 <2%). Fifty-two percent of patients had completely negative and 48% had weakly positive OctreoScan results. Thirty-two percent of these same patients had significantly positive 99mTc-depreotide scans (Krenning score≥2), with the histology demonstrating intermediate-grade or high-grade tumours. Conclusion 99mTc-depreotide imaging has low sensitivity but is useful in a one-third of OctreoScan-negative patients, displaying significantly better uptake than 111In-pentetreotide in this patient group. It aids diagnosis by highlighting lesions not seen by OctreoScan and/or CT/MRI imaging, and can possibly identify a group of patients amenable to therapy with radionuclide agents, such as SOM230, targeting somatostatin receptor subtypes 2, 3 and 5." @default.
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- W1978573089 date "2008-05-01" @default.
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- W1978573089 title "The role of 99mTc-depreotide in the management of neuroendocrine tumours" @default.
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- W1978573089 doi "https://doi.org/10.1097/mnm.0b013e3282f50747" @default.
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