Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978573346> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1978573346 endingPage "2453" @default.
- W1978573346 startingPage "2450" @default.
- W1978573346 abstract "Background —Blood flow characteristics influence endothelial cell apoptosis. However, little is known about the occurrence of endothelial cell apoptosis in human atherosclerosis and its relation to blood flow. Methods and Results —A total of 42 human carotid atherosclerotic plaques were retrieved by endarterectomy; they were examined in the longitudinal axial direction. Plaques were included in this study when upstream and downstream parts were clearly visible, occlusion was absent, and immunostaining for luminal endothelium was present all along the plaque. Using these criteria, 13 plaques were processed for further immunohistochemical studies (using anti-CD31, anti-Ki-67, and anti-splicing factor antibodies) and in situ detection of apoptosis (terminal dUTP nick end-labeling and ligase assay). Eight plaques showed ≥1 apoptotic endothelial cell at the luminal surface. Quantitative analysis of endothelial cell apoptosis in these plaques showed a systematic preferential occurrence of apoptosis in the downstream parts of plaques, where low flow and low shear stress prevail, in comparison with the upstream parts (18.8±3.3% versus 2.7±1.2%, respectively, P <0.001). Endothelial cell apoptosis was barely detectable in plaque microvessels. Conclusions —Our results suggest that in vivo local shear stress influences luminal endothelial cell apoptosis and may be a major determinant of plaque erosion and thrombosis." @default.
- W1978573346 created "2016-06-24" @default.
- W1978573346 creator A5018037890 @default.
- W1978573346 creator A5061562246 @default.
- W1978573346 creator A5069147686 @default.
- W1978573346 creator A5072120776 @default.
- W1978573346 creator A5075957404 @default.
- W1978573346 creator A5090767102 @default.
- W1978573346 date "2000-05-30" @default.
- W1978573346 modified "2023-10-14" @default.
- W1978573346 title "Relation Between Endothelial Cell Apoptosis and Blood Flow Direction in Human Atherosclerotic Plaques" @default.
- W1978573346 cites W124719744 @default.
- W1978573346 cites W1548742766 @default.
- W1978573346 cites W1607892649 @default.
- W1978573346 cites W17992636 @default.
- W1978573346 cites W1987262023 @default.
- W1978573346 cites W2009251691 @default.
- W1978573346 cites W2065577350 @default.
- W1978573346 cites W2065591461 @default.
- W1978573346 cites W2082593218 @default.
- W1978573346 cites W2130610092 @default.
- W1978573346 cites W2142792362 @default.
- W1978573346 cites W2412143783 @default.
- W1978573346 doi "https://doi.org/10.1161/01.cir.101.21.2450" @default.
- W1978573346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10831515" @default.
- W1978573346 hasPublicationYear "2000" @default.
- W1978573346 type Work @default.
- W1978573346 sameAs 1978573346 @default.
- W1978573346 citedByCount "342" @default.
- W1978573346 countsByYear W19785733462012 @default.
- W1978573346 countsByYear W19785733462013 @default.
- W1978573346 countsByYear W19785733462014 @default.
- W1978573346 countsByYear W19785733462015 @default.
- W1978573346 countsByYear W19785733462016 @default.
- W1978573346 countsByYear W19785733462017 @default.
- W1978573346 countsByYear W19785733462018 @default.
- W1978573346 countsByYear W19785733462019 @default.
- W1978573346 countsByYear W19785733462020 @default.
- W1978573346 countsByYear W19785733462021 @default.
- W1978573346 countsByYear W19785733462022 @default.
- W1978573346 countsByYear W19785733462023 @default.
- W1978573346 crossrefType "journal-article" @default.
- W1978573346 hasAuthorship W1978573346A5018037890 @default.
- W1978573346 hasAuthorship W1978573346A5061562246 @default.
- W1978573346 hasAuthorship W1978573346A5069147686 @default.
- W1978573346 hasAuthorship W1978573346A5072120776 @default.
- W1978573346 hasAuthorship W1978573346A5075957404 @default.
- W1978573346 hasAuthorship W1978573346A5090767102 @default.
- W1978573346 hasBestOaLocation W19785733461 @default.
- W1978573346 hasConcept C123012128 @default.
- W1978573346 hasConcept C126322002 @default.
- W1978573346 hasConcept C142724271 @default.
- W1978573346 hasConcept C1491633281 @default.
- W1978573346 hasConcept C190283241 @default.
- W1978573346 hasConcept C202751555 @default.
- W1978573346 hasConcept C204232928 @default.
- W1978573346 hasConcept C2776992346 @default.
- W1978573346 hasConcept C2778939058 @default.
- W1978573346 hasConcept C4224716 @default.
- W1978573346 hasConcept C54355233 @default.
- W1978573346 hasConcept C55493867 @default.
- W1978573346 hasConcept C71924100 @default.
- W1978573346 hasConcept C86803240 @default.
- W1978573346 hasConceptScore W1978573346C123012128 @default.
- W1978573346 hasConceptScore W1978573346C126322002 @default.
- W1978573346 hasConceptScore W1978573346C142724271 @default.
- W1978573346 hasConceptScore W1978573346C1491633281 @default.
- W1978573346 hasConceptScore W1978573346C190283241 @default.
- W1978573346 hasConceptScore W1978573346C202751555 @default.
- W1978573346 hasConceptScore W1978573346C204232928 @default.
- W1978573346 hasConceptScore W1978573346C2776992346 @default.
- W1978573346 hasConceptScore W1978573346C2778939058 @default.
- W1978573346 hasConceptScore W1978573346C4224716 @default.
- W1978573346 hasConceptScore W1978573346C54355233 @default.
- W1978573346 hasConceptScore W1978573346C55493867 @default.
- W1978573346 hasConceptScore W1978573346C71924100 @default.
- W1978573346 hasConceptScore W1978573346C86803240 @default.
- W1978573346 hasIssue "21" @default.
- W1978573346 hasLocation W19785733461 @default.
- W1978573346 hasLocation W19785733462 @default.
- W1978573346 hasOpenAccess W1978573346 @default.
- W1978573346 hasPrimaryLocation W19785733461 @default.
- W1978573346 hasRelatedWork W1964517198 @default.
- W1978573346 hasRelatedWork W2022498945 @default.
- W1978573346 hasRelatedWork W202920663 @default.
- W1978573346 hasRelatedWork W2031345631 @default.
- W1978573346 hasRelatedWork W2079153990 @default.
- W1978573346 hasRelatedWork W2084136175 @default.
- W1978573346 hasRelatedWork W2088783977 @default.
- W1978573346 hasRelatedWork W2407881497 @default.
- W1978573346 hasRelatedWork W2413359840 @default.
- W1978573346 hasRelatedWork W3128284137 @default.
- W1978573346 hasVolume "101" @default.
- W1978573346 isParatext "false" @default.
- W1978573346 isRetracted "false" @default.
- W1978573346 magId "1978573346" @default.
- W1978573346 workType "article" @default.