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• W1978575105 abstract "Abstract Purpose: To evaluate the differences in image quality of two macrocyclic gadolinium‐based contrast agents, gadobutrol and gadoterate meglumine, using time‐resolved, contrast‐enhanced MR angiography (CE‐MRA) in a porcine carotid artery aneurysm model and to compare image quality between dynamic and conventional, single acquisition CE‐MRA. Materials and Methods: Bilateral carotid aneurysms were created surgically in this Institutional Animal Care and Use Committee approved study. Dynamic CE‐MRA studies optimized for high temporal resolution were performed at 3 Tesla. Scans using equivalently dosed (on a per mmol basis) gadobutrol and gadoterate meglumine were compared qualitatively and quantitatively in terms of contrast‐to‐noise ratio (CNR). Higher spatial resolution dynamic and conventional CE‐MRA were also compared. Results: N = 16 aneurysms were assessed. Qualitative evaluation of dynamic CE‐MRA scans demonstrated a preference for gadobutrol over gadoterate meglumine. Significantly higher aneurysm CNR was found with gadobutrol (133 ± 44) versus gadoterate meglumine, the latter at both equivalent and double injection rates (94 ± 35 and 102 ± 38). In a blinded assessment, conventional CE‐MRA was preferred qualitatively when compared with dynamic CE‐MRA. However, dynamic CE‐MRA was generally capable of providing diagnostic image quality. Conclusion: Gadobutrol is preferred to gadoterate meglumine for high temporal resolution dynamic CE‐MRA, a fact with important clinical implications for low dose CE‐MRA protocols in patients at risk for nephrogenic systemic fibrosis. Conventional high resolution CE‐MRA provides superior image quality when compared with dynamic CE‐MRA. J. Magn. Reson. Imaging 2012;36:1203–1212. © 2012 Wiley Periodicals, Inc." @default.
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• W1978575105 date "2012-07-23" @default.
• W1978575105 modified "2023-10-12" @default.
• W1978575105 title "MR angiography of carotid artery aneurysms in a porcine model at 3 tesla: Comparison of two different macrocyclic gadolinium chelates and of dynamic and conventional techniques" @default.
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• W1978575105 doi "https://doi.org/10.1002/jmri.23757" @default.
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