Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978576543> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1978576543 endingPage "447" @default.
- W1978576543 startingPage "435" @default.
- W1978576543 abstract "An unfractionated heparin (UFH) and a depolymerised derivative of low molecular weight heparin (LMWH) have been compared for their ability to activate platelets suspended in citrated plasma (PRP) or after washing and suspension in hepes buffered tyrode containing fibrinogen. Neither heparin alone induced aggregation of washed platelets, but UFH and to a much lesser extent LMWH, induced aggregation of platelets in PRP. Both heparins caused significant enhancement of a low concentration of ADP-induced activation of PRP and, again, the effect of LMWH was somewhat less than that of UFH. UFH produced a marked potentiation of ADP-induced activation of washed platelets and LMWH was about a third as potent. In addition, UFH induced a potentiation of PAF-induced aggregation and dense-granule release in PRP, a property not shared by LMWH. In PRP, UFH was three times more potent at inhibiting thrombin-induced aggregation and dense-granule release, as might be expected from their specific activities in the KCCT and thrombin time assay. However, with washed platelets, both heparins were equivalent at inhibiting thrombin-induced aggregation, dense-granule release and elevation of cytosolic free calcium ([Ca++]i) as monitored by quin 2 fluorescence. UFH and LMWH alone did not induce a change in [Ca++]i, nor had they any effect on ADP- or PAF-induced elevation of [Ca++]i." @default.
- W1978576543 created "2016-06-24" @default.
- W1978576543 creator A5008818690 @default.
- W1978576543 creator A5032500888 @default.
- W1978576543 creator A5063798906 @default.
- W1978576543 creator A5090806346 @default.
- W1978576543 date "1986-05-01" @default.
- W1978576543 modified "2023-09-23" @default.
- W1978576543 title "Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro" @default.
- W1978576543 cites W1567089653 @default.
- W1978576543 cites W1608119064 @default.
- W1978576543 cites W1973109750 @default.
- W1978576543 cites W1987672928 @default.
- W1978576543 cites W2029384334 @default.
- W1978576543 cites W2039396916 @default.
- W1978576543 cites W2045030382 @default.
- W1978576543 cites W2057916362 @default.
- W1978576543 cites W2058198964 @default.
- W1978576543 cites W2061309862 @default.
- W1978576543 cites W2065993385 @default.
- W1978576543 cites W2066156655 @default.
- W1978576543 cites W2076315269 @default.
- W1978576543 cites W2086808806 @default.
- W1978576543 cites W2089177809 @default.
- W1978576543 cites W2094866602 @default.
- W1978576543 cites W2106140516 @default.
- W1978576543 cites W2112799238 @default.
- W1978576543 cites W2153545493 @default.
- W1978576543 cites W2331772974 @default.
- W1978576543 cites W2783027397 @default.
- W1978576543 doi "https://doi.org/10.1016/0049-3848(86)90207-0" @default.
- W1978576543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3715810" @default.
- W1978576543 hasPublicationYear "1986" @default.
- W1978576543 type Work @default.
- W1978576543 sameAs 1978576543 @default.
- W1978576543 citedByCount "54" @default.
- W1978576543 countsByYear W19785765432012 @default.
- W1978576543 countsByYear W19785765432013 @default.
- W1978576543 countsByYear W19785765432020 @default.
- W1978576543 crossrefType "journal-article" @default.
- W1978576543 hasAuthorship W1978576543A5008818690 @default.
- W1978576543 hasAuthorship W1978576543A5032500888 @default.
- W1978576543 hasAuthorship W1978576543A5063798906 @default.
- W1978576543 hasAuthorship W1978576543A5090806346 @default.
- W1978576543 hasConcept C12554922 @default.
- W1978576543 hasConcept C178790620 @default.
- W1978576543 hasConcept C185592680 @default.
- W1978576543 hasConcept C202751555 @default.
- W1978576543 hasConcept C203014093 @default.
- W1978576543 hasConcept C2776884760 @default.
- W1978576543 hasConcept C2777292125 @default.
- W1978576543 hasConcept C2777557582 @default.
- W1978576543 hasConcept C2779036427 @default.
- W1978576543 hasConcept C3018697912 @default.
- W1978576543 hasConcept C519063684 @default.
- W1978576543 hasConcept C55493867 @default.
- W1978576543 hasConcept C71924100 @default.
- W1978576543 hasConcept C86803240 @default.
- W1978576543 hasConcept C89560881 @default.
- W1978576543 hasConcept C98274493 @default.
- W1978576543 hasConceptScore W1978576543C12554922 @default.
- W1978576543 hasConceptScore W1978576543C178790620 @default.
- W1978576543 hasConceptScore W1978576543C185592680 @default.
- W1978576543 hasConceptScore W1978576543C202751555 @default.
- W1978576543 hasConceptScore W1978576543C203014093 @default.
- W1978576543 hasConceptScore W1978576543C2776884760 @default.
- W1978576543 hasConceptScore W1978576543C2777292125 @default.
- W1978576543 hasConceptScore W1978576543C2777557582 @default.
- W1978576543 hasConceptScore W1978576543C2779036427 @default.
- W1978576543 hasConceptScore W1978576543C3018697912 @default.
- W1978576543 hasConceptScore W1978576543C519063684 @default.
- W1978576543 hasConceptScore W1978576543C55493867 @default.
- W1978576543 hasConceptScore W1978576543C71924100 @default.
- W1978576543 hasConceptScore W1978576543C86803240 @default.
- W1978576543 hasConceptScore W1978576543C89560881 @default.
- W1978576543 hasConceptScore W1978576543C98274493 @default.
- W1978576543 hasIssue "4" @default.
- W1978576543 hasLocation W19785765431 @default.
- W1978576543 hasLocation W19785765432 @default.
- W1978576543 hasOpenAccess W1978576543 @default.
- W1978576543 hasPrimaryLocation W19785765431 @default.
- W1978576543 hasRelatedWork W2008483939 @default.
- W1978576543 hasRelatedWork W2017755911 @default.
- W1978576543 hasRelatedWork W2030531522 @default.
- W1978576543 hasRelatedWork W2031639269 @default.
- W1978576543 hasRelatedWork W2072171268 @default.
- W1978576543 hasRelatedWork W2091494205 @default.
- W1978576543 hasRelatedWork W2371755933 @default.
- W1978576543 hasRelatedWork W2401678231 @default.
- W1978576543 hasRelatedWork W2464800971 @default.
- W1978576543 hasRelatedWork W4256484403 @default.
- W1978576543 hasVolume "42" @default.
- W1978576543 isParatext "false" @default.
- W1978576543 isRetracted "false" @default.
- W1978576543 magId "1978576543" @default.
- W1978576543 workType "article" @default.