FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978595303> ?p ?o ?g. }

• W1978595303 endingPage "349" @default.
• W1978595303 startingPage "338" @default.
• W1978595303 abstract "The globus pallidus (GP) plays a central integrative role in the basal ganglia circuitry. It receives strong GABAergic inputs from the striatum (Str) and significant glutamatergic afferents from the subthalamic nucleus (STN). The change in firing rate and pattern of GP neurons is a cardinal feature of Parkinson’s disease pathophysiology. Kainate receptor (KAR) GluR6/7 subunit immunoreactivity is expressed presynaptically in GABAergic striatopallidal terminals which provides a substrate for regulation of GABAergic transmission in GP. To test this hypothesis, we recorded GABAA-mediated inhibitory postsynaptic currents (IPSCs) in the GP following electrical stimulation of the Str. Following blockade of AMPA and N-methyl-d-aspartate receptors with selective antagonists, bath application of kainate (KA) (0.3–3 μM) reduced significantly the amplitude of evoked IPSCs. This inhibition was associated with a significant increase in paired-pulse facilitation ratio and a reduction of the frequency, but not amplitude, of miniature inhibitory postsynaptic currents (mIPSCs), suggesting a presynaptic site of KA action. The KA effects on striatopallidal GABAergic transmission were blocked by the G-protein inhibitor, N-ethylmaleimide (NEM), or protein kinase C (PKC) inhibitor calphostin C. Our results demonstrate that KAR activation inhibits GABAergic transmission through a presynaptic G protein–coupled, PKC-dependent metabotropic mechanism in the rat GP. These findings open up the possibility for the development of KA-mediated pharmacotherapies aimed at decreasing the excessive and abnormally regulated inhibition of GP neurons in Parkinson’s disease." @default.
• W1978595303 created "2016-06-24" @default.
• W1978595303 creator A5029855160 @default.
• W1978595303 creator A5051289855 @default.
• W1978595303 date "2007-10-01" @default.
• W1978595303 modified "2023-09-26" @default.
• W1978595303 title "Activation of presynaptic kainate receptors suppresses GABAergic synaptic transmission in the rat globus pallidus" @default.
• W1978595303 cites W1483198065 @default.
• W1978595303 cites W1510554078 @default.
• W1978595303 cites W1526327880 @default.
• W1978595303 cites W1550887894 @default.
• W1978595303 cites W1553854216 @default.
• W1978595303 cites W1587307227 @default.
• W1978595303 cites W1637705010 @default.
• W1978595303 cites W1962526731 @default.
• W1978595303 cites W1967701945 @default.
• W1978595303 cites W1968669125 @default.
• W1978595303 cites W1970753953 @default.
• W1978595303 cites W1972474164 @default.
• W1978595303 cites W1974630446 @default.
• W1978595303 cites W1978836458 @default.
• W1978595303 cites W1982827121 @default.
• W1978595303 cites W1985415750 @default.
• W1978595303 cites W1985423204 @default.
• W1978595303 cites W1989566057 @default.
• W1978595303 cites W1991202463 @default.
• W1978595303 cites W1992933456 @default.
• W1978595303 cites W1995925139 @default.
• W1978595303 cites W1998242737 @default.
• W1978595303 cites W2002478276 @default.
• W1978595303 cites W2010809203 @default.
• W1978595303 cites W2014810233 @default.
• W1978595303 cites W2015913538 @default.
• W1978595303 cites W2024844578 @default.
• W1978595303 cites W2025896287 @default.
• W1978595303 cites W2026031011 @default.
• W1978595303 cites W2038505488 @default.
• W1978595303 cites W2046046616 @default.
• W1978595303 cites W2048220035 @default.
• W1978595303 cites W2055973927 @default.
• W1978595303 cites W2057196059 @default.
• W1978595303 cites W2060561729 @default.
• W1978595303 cites W2066987730 @default.
• W1978595303 cites W2078078069 @default.
• W1978595303 cites W2081245229 @default.
• W1978595303 cites W2082442002 @default.
• W1978595303 cites W2082607979 @default.
• W1978595303 cites W2087156861 @default.
• W1978595303 cites W2090430619 @default.
• W1978595303 cites W2091215810 @default.
• W1978595303 cites W2100519696 @default.
• W1978595303 cites W2108319380 @default.
• W1978595303 cites W2112923968 @default.
• W1978595303 cites W2113171895 @default.
• W1978595303 cites W2123609069 @default.
• W1978595303 cites W2126196281 @default.
• W1978595303 cites W2129108032 @default.
• W1978595303 cites W2129227566 @default.
• W1978595303 cites W2131586229 @default.
• W1978595303 cites W2131784236 @default.
• W1978595303 cites W2134230622 @default.
• W1978595303 cites W2136197879 @default.
• W1978595303 cites W2137513442 @default.
• W1978595303 cites W2143563675 @default.
• W1978595303 cites W2150498136 @default.
• W1978595303 cites W2152904049 @default.
• W1978595303 cites W2163239527 @default.
• W1978595303 cites W2171601518 @default.
• W1978595303 cites W2273738402 @default.
• W1978595303 cites W2403345187 @default.
• W1978595303 cites W2990007984 @default.
• W1978595303 cites W4230066598 @default.
• W1978595303 cites W4253409128 @default.
• W1978595303 doi "https://doi.org/10.1016/j.neuroscience.2007.07.017" @default.
• W1978595303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175023" @default.
• W1978595303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17881134" @default.
• W1978595303 hasPublicationYear "2007" @default.
• W1978595303 type Work @default.
• W1978595303 sameAs 1978595303 @default.
• W1978595303 citedByCount "22" @default.
• W1978595303 countsByYear W19785953032012 @default.
• W1978595303 countsByYear W19785953032013 @default.
• W1978595303 countsByYear W19785953032014 @default.
• W1978595303 countsByYear W19785953032018 @default.
• W1978595303 countsByYear W19785953032019 @default.
• W1978595303 countsByYear W19785953032020 @default.
• W1978595303 countsByYear W19785953032021 @default.
• W1978595303 countsByYear W19785953032023 @default.
• W1978595303 crossrefType "journal-article" @default.
• W1978595303 hasAuthorship W1978595303A5029855160 @default.
• W1978595303 hasAuthorship W1978595303A5051289855 @default.
• W1978595303 hasBestOaLocation W19785953032 @default.
• W1978595303 hasConcept C126322002 @default.
• W1978595303 hasConcept C160268369 @default.
• W1978595303 hasConcept C169760540 @default.
• W1978595303 hasConcept C170493617 @default.
• W1978595303 hasConcept C17077164 @default.
• W1978595303 hasConcept C189184402 @default.

• next